University of Minnesota

Narsihmulu Cheryala

Ingrid Gunda Georg

Gunda I Georg

James C Cloyd

Ronald A Siegel

Mamta Kapoor

Sudhakar Jakkaraj

Samuel Dudley

The invention provides a compound of formula (I): or a salt thereof, wherein A, B, R, R, Rand X have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as therapeutic agents for treating diastolic dysfunction.

Therapeutic compounds and methods of use thereof

The invention provides a compound of formula (I):

Contraceptive compounds and methods

The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, wherein R-Rhave any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as contraceptive agents.

Certain embodiments of the invention provide a formulation suitable for nasal administration comprising water, a prodrug of a therapeutic agent, and an enzyme that is suitable for intranasal conversion of the prodrug to the therapeutic agent, as well as methods of use thereof.

Growing community of inventors

Minneapolis, MN, United States of America

Narsihmulu Cheryala