Merck + Co., Inc.

Narindar N Girotra

Matthew J Wyvratt

Mark T Goulet

Mitree M Ponpipom

Lin Chu

Peter Lin

Tesfaye Biftu

Michael H Fisher

Wallace T Ashton

Robert M Burk

William H Parsons

Robert L Bugianesi

Gregory D Berger

James D Bergstrom

Lori L Whiting

Thomas F Walsh

Donald W Graham

Danqing D Feng

Jonathan R Young

XiaoXia Qian

Shu S Yang

John J Acton, Iii

Yuan-Ching P Chiang

Norman L Wendler

Gui-Bai Liang

Conrad Santini

Claude Dufresne

Chan-Hwa Kuo

Robert W Marquis, Jr

Zbigniew S Zelawski, Deceased

Michael H Fischer

C H Kuo

Sandra P Plevyak

Trisubstituted pyrroles are antiprotozoal agents useful in the treatment and prevention of protozoal diseases in human and animals, including the control of coccidiosis in poultry.

Aliphatic amine substituted piperidyl diaryl pyrrole derivatives as antiprotozoal agents

There are disclosed compounds of formula (I)

Antagonists of gonadotropin releasing hormone

There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

Cholesterol lowering compounds

This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer.

Cholesterol-lowering agents

The compounds of the following structural formula (I) ##STR1## ar 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.

Antihypercholesterolemic .beta.-lactones

A method for the total chemical synthesis of flavipucine employs the condensation of 4-hydroxy-6-methyl-2-pyridone with isobutylglyoxal in alkali alkoxide. The resulting alkali salt is acylated in both the 1' and 4 positions. Treatment of the 1',4-diacyloxy derivative with excess alkaline peroxide yields flavipucine.

Chemical synthesis of flavipucine

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Old Bridge, NJ, United States of America

Narindar N Girotra