Freund Industrial Co., Ltd.

Freund Inphachem Inc.

Shionogi Company Limited

Freund Industrial Col, Ltd.

Narimichi Takei

Kazuomi Unosawa

Nagahiko Tanaka

Kaoru Kurita

Kuniaki Yamanaka

Shimesu Motoyama

Shuri Yamada

Shigeru Ohno

Masanori Ogawa

Mamoru Sugiyama

Shizuka Sakashita

Takashi Watanabe

Yasutoyo Fusejima

Shigemi Isobe

Takuichi Tsujino

Hideyuki Akiyama

Tsugutoshi Yamada

Kiyoshi Nishiyama

Kei Takebayashi

Kaora Kurita

Hiroyuki Ooishi

Koji Nagaka

Nobuyuki Hirono

Siuri Yamada

Takehiko Itou

Syuri Yamada

Under the granulating sectionfor performing fluidized-bed granulation coating of powder grains, a drying sectionfor drying powder grains granulated is provided. A drying sectionfor drying the powder grains that are not sufficiently dried is provided under the drying section. A product discharging sectionfor discharging a dried product is provided under the drying section. A fluidized-bed forming-gas is supplied downward to upward, and granulation and dryness are continuously performed by the fluidized-bed forming-gas, and the powder grains moved from the granulating section to the drying section located immediately thereunder are pneumatic classified.

Fluidized bed granulation coating device and fluidized bed granulation coating method

An upper processing section is provided by evenly spacing out functional stations having respective functions of steps constituting a fluidized bed granulation coating process, on circumferential points. An intermediate storing section is provided under the upper processing section by evenly spacing out powder grain storing vessels corresponding to the plurality of functional stations on circumferential points. A lower gas supply section is provided under the intermediate storing section by evenly spacing out gas supply stations corresponding to the plurality of powder grain storing vessels The powder grain storing vessels storing powder grains sequentially proceed to the respective functional stations to execute respective processes to the powder grains, and thereby granulation coating of the powder grains is performed in a batch type and a continuous type. Alternatively, the plurality of functional stations having respective functions of steps constituting the fluidized bed granulation coating process may be disposed on a straight line.

Fluidized bed granulation coating device, and fluidized bed granulation coating method

Particle measuring device for granule processing apparatus and particle

A centrifugal tumbling granulating-coating apparatus for spherically granulating and coating pharmaceuticals, foods and the like. The apparatus is constructed such that an annular outer portion 5b of a rotary disc 5 is formed to provide an inclined portion which is inclined downwardly toward the center, the size (P) of the outer portion 5b in the horizontal direction is within the range of P.gtoreq.0.25D to the diameter (D) and preferably 0.4D.gtoreq.P.gtoreq.0.25D, and the height (H) is within the range of 0.1D.ltoreq.H.ltoreq.0.33D and preferably 0.1D.ltoreq.H.ltoreq.0.25D.

Centrifugal tumbling granulating-coating apparatus, method of

A centrifugal tumbling granulating-coating apparatus has a rotary disk rotated in the horizontal direction and a stator provided at an outer peripheral position of the rotary disk at a predetermined internal from the rotary disk. The rotary disk is formed therein with a peripheral edge portion having a circularly arcuate-shaped vertical cross-section erected from a flat bottom surface portion and curved upwardly. In the rotary disk, a height (H) from the bottom surface portion to an outer peripheral end is set at a value within a range of 0.30R.ltoreq.H.ltoreq.R to a radius of curvature (R) of the peripheral edge portion, a width (W) of the peripheral edge portion is set at a value within a range of 0.07D.ltoreq.W.ltoreq.0.25D to a diameter (D) of the rotary disk and the radius of curvature (R) of the peripheral edge portion is set at a value within a range of 0.10D.ltoreq.R.ltoreq.0.25D to the diameter (D). A powder contact portion of the stator is formed substantially vertically. By use of this centrifugal tumbling granulating-coating apparatus, a powder or granular material in more quantities per batch can be granulated and coated.

Centrifugal tumbling granulating-coating apparatus

The rotary drum has a cylindrical portion (tubular body portion) formed therein with vent holes. An annular duct is disposed at the outside of the cylindrical portion of the rotary drum in a manner to surround the cylindrical portion. This annular duct is provided with a gas supply duct and an exhaust duct. In the annular duct, partition walls define a vent path, in which the drying gas which has been supplied from the gas supply duct flows through an accumulated layer, and thereafter, flows to the exhaust duct. The direction of flow of the drying gas in the vent path is changed over by gas supply-exhaust changeover dampers.

Granular material coating apparatus

An apparatus for applying a coating to a powdery or granular material has a rotary drum 20 including a tubular portion 21 formed with air holes 27 and hollow shaft portions 23 and 24 provided at opposite end portions in the axial direction. A coating chamber 26 is defined inside the rotary drum 20. Liquid is sprayed from a nozzle 32 onto an accumulated layer 33 of a powdery or granular material in the coating chamber 26. Drying gas supplied from an air supply duct 45 is introduced into the rotary drum 20 from one of the two hollow shaft portions 23 and 24. A plurality of axially extending air ducts 34 are provided on the outer periphery of the rotary drum 20. When an air duct is positioned downwardly it is communicated with an air exhaust duct 41 through a distributor 35. Air introduced from the air supply duct 45 is biased toward the accumulated layer 33 by louvers 48.

Pan coating apparatus with louvered air supply guide

A method of and an apparatus for sugar coating, the apparatus comprising: a rotatable vessel for containing a material to be coated; a baffle 9 movable independently of the rotatable vessel; a baffle mounting shaft 10 having a bent construction, for mounting the baffle 9 thereon; and a hydraulic cylinder for rocking the baffle mounting shaft 10 to displace the baffle 9. Load cells 17a and 17b for detecting the position of the baffle 9 relative to an accumulated layer M of a material to be coated are provided on the baffle 9. The load cells 17a and 17b serves for holding the position of the baffle 9 relative to the accumulated layer M of the material to be coated at all times, on the basis of a load imposed due to the presence of the contact with the material to be coated.

Method of sugar coating and apparatus therefor

A prolonged release dosage form of drug made by coating a surface of an ungranulated medicinal particle with a water-insoluble material which is physiologically acceptable and does not dissolve in water and gastric juice; and then, granulating or tableting the coated medicinal particles.

Prolonged release dosage form of drug and method for producing the same

Apparatus for coating powdery material

A pan coating apparatus wherein a blow-out portion is provided at the forward end of an air supply pipe inserted into a rotatable container, and the total opening area of gas outlets provided in the blow-out portion is set at 0.1-1 time that of perforations provided in a perforated plate of the rotatable container.

Pan coating apparatus

An apparatus for manufacturing seamless capsules is provided with a multiple nozzle which blows multilayer liquid drops into a hardening liquid. The hardening liquid flows through a main flow path and an auxiliary flow path. The flow of hardening liquid through the main flow path is biased in a direction intersecting the main flow path by a flow of hardening liquid into the main flow path from the auxiliary flow path or a discharge of the hardening liquid from the main flow path into the auxiliary flow path.

Apparatus for manufacturing seamless capsules

A method of manufacturing seamless capsules, wherein multi-layer liquid flow is blown out of a multiple nozzle to form multi-layer droplets which are brought into contact with hardening liquid to be solidified to thereby manufacture the seamless capsules SC and an apparatus therefor. A groove having U-shaped section for supplying the hardening liquid and the multi-layer droplets is orientated in a direction tangent to a circular section of a hardening vessel in the hardening vessel and a helical flow is formed in the hardening liquid in the hardening vessel, whereby the multi-layer droplets are fallen, moving helically in the hardening vessel.

Method of manufacturing seamless capsules and apparatus therefor

An apparatus for manufacturing seamless capsules having satisfactory multilayer liquid drops without deformation, wherein a multilayer liquid flow is blown out of a multiple nozzle to form multilayer liquid drops which are brought into contact with hardening liquid for manufacturing seamless capsules, and a nozzle moving device is connected to the multiple nozzle, whereby the multiple nozzle is movably adjustable by this nozzle moving device in a direction intersecting or preferably perpendicular to the flow of the hardening liquid in a flow path of the hardening liquid.

A method of performing granulating, coating, drying of a powdry or granular material having a relatively minute particle diameter and an apparatus therefor. A nozzle for supplying the powdery or granular material and a nozzle for supplying a coating liquid are parallelly provided at adjacent positions where air streams dispersed from the both nozzles are not in contact with each other and directed to the interior of a processing cylinder. The two nozzles are connected to compressed air sources independently of each other. Drying air-stream blow-in openings are provided on the way from collision of the powdery or granular material and the coating material to catching thereof. Drying air streams are supplied from a direction tangent to the processing cylinder having a circular section.

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Tokyo, Japan

Narimichi Takei