Takeda Chemical Industries, Inc.

Nariakira Mizokami

Satoshi Horii

Yutaka Kuwada

Yukihiko Kameda

Novel 2-methylcephalosporin derivatives and production thereof. These cephalosporin derivatives exhibit excellent antibacterial activities against gram-positive and gram-negative bacteria, thus being of value as a prophylactic or therapeutic agent for infections observed in man and animals.

Process for producing 2-methyl cephem-2-em and 2-methylcephem-3-em

A new deoxystreptamine-containing aminoglycoside antibiotic derivative in which all the amino groups other than the amino group at the 1-position of the deoxystreptamine moiety are formylated is obtained in a high yield by treating a deoxystreptamine-containing aminoglycoside antibiotic derivative in which all the amino groups are formylated with a basic substance. The new derivatives are very important for production of 1-N-modified deoxystreptamine-containing aminoglycoside antibiotics.

Growing community of inventors

Suita, Japan

Nariakira Mizokami