University of Colorado

Clarvista Medical, Inc.

Alcon, Inc.

Abbott Medical Optics Inc.

Endoshape, Inc.

Clarviata Medical, Inc.

Naresh Mandava

Malik Y Kahook

Robert E Atkinson

Paul McLean

Robin Shandas

Bryan Rech

Glenn R Sussman

Paul Mclean

Michael D Lowery

Jeffrey L Olson

Daniel Urbaniak

Anthony V Caparso

Michael B Lyons

Jeffrey Paul Castleberry

Julie Marie Trommeter

Noah Lemire

James Fogelberg

Steve Wilder

Steve Risser

Adam Farwick

Jeffrey Olson

A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component may be manipulated, removed, and/or exchanged for a different secondary component for correction or modification of the optical result, on an intra-operative or post-operative basis, without the need to remove the primary component and without the need to manipulate the capsular bag. The primary component may have haptics extending therefrom for centration in the capsular bag, and the secondary component may exclude haptics, relying instead on attachment to the primary component for stability. Such attachment may include actuatable interlocking members.

Modular intraocular lens designs and methods

Described are systems and methods for preventing, diagnosing, and/or treating one or more medical conditions. The medical conditions can be ocular and/or neurological diseases, disorders, and/or conditions. The systems and methods can employ a microstimulator that is configured to be placed within an anatomical structure of a subject. The microstimulator can be capacitively linked to an external electronic device to provide neuromodulation to a biological target site proximal to the anatomical structure. The microstimulator can include a body and an electrically conductive insert arranged within the body to create a capacitively coupled link with the external electronic device. The electrically conductive insert can receive a power signal from an external electronic device and convert the power signal to deliver a therapy signal to the biological target site.

Systems and methods for preventing, diagnosing, and/or treating one or more medical conditions via neuromodulation

The present disclosure relates to a structure used in an ophthalmic surgical procedure. The device may be used in pupil expansion or stabilization of the iris. The device is made out of an elastic or semielastic material in a shape that is conducive to easy insertion and removal as well as being optimized for atraumatic pupil expansion.

Ocular tissue expansion ring

A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10&#xb0; C. and 60&#xb0; C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

Intraocular lenses

A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10&#xb0; C. and 60&#xb0; C., inclusive, de minimiz or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

Shape memory polymer intraocular lenses

A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10&#xb0; C. and 60&#xb0; C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45

A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component may be manipulated, removed, and/or exchanged for a different secondary component for correction or modification of the optical result, on an intra-operative or post-operative basis, without the need to remove the primary component and without the need to manipulate the capsular bag. The primary component may have haptics extending therefrom for centration in the capsular bag, and the secondary component may exclude haptics, relying instead on attachment to the primary lens for stability. Such attachment may reside radially inside the perimeter of the capsulorhexis and radially outside the field of view to avoid interference with light transmission.

An improved method for stimulating electrical activity in an eye is provided. Provided is a technique for implanting small, nanometer-sized photoactive devices into an eye to improve electrical activity within an eye or mitigate degradation of electrical response in damaged eyes.

Method for stimulating retinal response using photoactive devices

Growing community of inventors

Denver, CO, United States of America

Naresh Mandava