Novogen Research Pty Limited

Unisearch Limited

Unisearch Limited, A.c.n.

Newsouth Innovations Pty Limited

Marshall Edwards, Inc.

Bio-signal Corporation Ltd.

Unilever Plc

Naresh Kumar

Andrew Heaton

Roger Wayne Read

Graham Edmund Kelly

George Iskander

Alan James Husband

Mark Wilcox

Hua Zhu

Tim Hughes

Shashidhar Nizalapur

Tsz Tin Yu

Mark Duncan Perry Willcox

Rajesh Kuppusamy

Catherine Walker

Hnas Griesser

David Stc Black

Ben Muir

Helmut Thissen

The present application relates to compounds of Formula (I) and salts thereof. The compounds of Formula (I) have antibacterial and anti-biofilm activities. The present application also relates to compositions comprising the compounds of Formula (I) or salts thereof, methods of treating or preventing bacterial infections using the compounds of Formula (I) or salts thereof, and methods of inhibiting biofilm formation using the compounds of Formula (I) or salts thereof. 

Antimicrobial compounds

Lactams of formulae (I) and (II) and their use in the treatment of microbial infections and microbial contamination of surfaces, particularly infections and surface contaminations characterized by biofilm formation. Compounds of formula (I) and (II) substituted with acrylate or methacrylate groups and their attachment to surfaces or polymers to inhibit microbial contamination are also provided.

Lactams

The present invention provides a compound of formula I and a compound of formula II, methods of use and formulations thereof. 

Furanone compounds and lactam analogues thereof

The invention provides oxazinyl isoflavonoid compounds and compositions containing same, methods for their preparation and their use as therapeutic agents particularly as cardioprotective, anti-inflammatory, anti-oxidant and chemotherapeutic agents.

Oxazinyl isoflavonoid compounds, medicaments and use

Methods for the hydrogenation of isoflavones are described which provide access to workable quantities of isoflavan-4-ols, isoflav-3-enes, and isoflavans. The isoflavone derivatives can be obtained in high purity and in near quantitative yields whilst employing pharmaceutically acceptable reagents and solvents.

Production of isoflavone derivatives

Novel compounds based on phenyl-substituted naphtho[1,2-g]chrysene compounds (A) are described. The compounds are obtainable by dimerisation of 3-phenylchroman (isoflavonoid) ring systems (B). Methods of synthesis of the novel dimeric compounds, compositions containing same and use of the dimers as therapeutic agents are also described. 

Isoflavonoid dimers

The present invention provides a substrate having a plurality of immobilised furanone moieties associated with at least part of a surface of the substrate. The invention also relates to articles consisting of or comprising such a substrate.

Antimicrobial coatings

Isoflavone compounds are described and recommended as therapeutic agents. Exemplified and preferred compounds are (a). Indications show compounds have good competitive binding to estrogen receptors. This is exemplified 

Compositions and therapeutic methods involving isoflavones and analogues thereof

The present invention relates to the side chain functionalization of fimbrolides (halogenated 3-alkyl-5-methylene-2(5H)-furanones) and their synthetic analogues, that yields fimbrolides substituted with a halogen, an oxygen or a nitrogen functionality in the alkyl chain, especially fimbrolide alcohols, carboxylate and sulfinate and sulfonate esters, ethers, aldehydes, ketones, acids, amides, nitro derivatives, hydrophobic, hydrophilic and fluorophilic alkyl derivatives and polymers.

Production of furanones

A compound of the general formula (I) or (II) wherein X is O, NRor S and R-Rare as defined in the specification 

Dimeric isoflavones

The present invention relates to the side chain functionalization of fimbrolides (halogenated 3-alkyl-5-methylene-2(5H)-furanones) and their synthetic analogues, that yields fimbrolides substituted with a halogen, an oxygen or a nitrogen functionality in the alkyl chain, especially fimbrolide alcohols, carboxylate and sulfinate and sulfonate esters, ethers, aldehydes, ketones, acids, amides, nitro derivatives, hydrophobic, hydrophilic and fluorophilic alkyl derivatives and a polymers.

A method for the preparation of a compound of formula (II) wherein Rand Rare independently H, alkyl, alkoxy, oxoalkyl, alkenyl, aryl or arylalkyl whether unsubstituted or substituted, optionally interrupted by one or more hetero atoms, straight chain or branched chain, hydrophilic, hydrophobic or fluorophilic; R, R, Rand Rare independently or all hydrogen or halogen; provided that at least two of the R, R, Rand Rare halogens.

Growing community of inventors

Maroubra, Australia

Naresh Kumar