Glenmark Pharmaceuticals Limited

Glenmark Generics Limited

Narendra Shriram Joshi

Shekhar Bhaskar Bhirud

Nitin Sharad Chandra Pradhan

Batchu Chandrasekhar

Sankar Arjunan

Biju Kumar Gopinathen Pillai

Kodali Eswara Rao

Buddhavarapu Pattabhi Ramam

Vijay Soni

K Eswara Rao

Subhash Damle

A substantially pure dextrorotatory isomer of zopiclone or a pharmaceutically acceptable salt thereof and crystalline forms thereof are provided. Also provided is a process for its preparation and pharmaceutical compositions containing same.

Process for the preparation of an optically active 5H-pyrrolo [3,4-B] pyrazine derivative

An improved process for the preparation of pyrimidine derivatives is provided comprising reacting a Wittig reagent of the general formula wherein R is an alkyl of from 1 to 10 carbon atoms, aryl or arylalkyl, Ris a substituted or unsubstituted hydrocarbon group, Rand Rare the same or different and are hydrogen or a substituted or unsubstituted hydrocarbon group; Z is sulfur, oxygen, sulfonyl, or imino which may be substituted by formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, amino substituted by sulfonyl or alkylsulfonyl, and sulfonyl substituted by alkyl, amino or alkylamino and X is a halogen; with an aldehyde of the general formula wherein Ris hydrogen, a lower alkyl or a cation capable of forming a non-toxic pharmaceutically acceptable salt and each Rare the same or different and are hydrogen or a hydrolyzable protecting group, or each R, together with the oxygen atom to which each is bonded, form a hydrolyzable cyclic protecting group, or each Ris bonded to the same substituent which is bonded to each oxygen atom to form a hydrolyzable protecting group; in the presence of a base.

Process for the preparation of pyrimidine derivatives

A process for preparing perindopril is provided comprising condensing an N-[(S)-1-carbethoxybutyl]-(S)-alanyl halide of formula II: wherein X is a halide with an (2S,3aS,7aS)-2-carboxyperhydroindole of formula III: wherein R is hydrogen or a protecting group.

Process for the preparation of perindopril

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Navi Mumbai, India

Narendra Shriram Joshi