Emcure Pharmaceuticals Limited

Emcure Pharmaceutical Limited

Narendra Kumar Tripathy

Mukund Keshav Gurjar

Samit Satish Mehta

Golakchandra Sudarshan Maikap

Rajendra Dagesing Mahale

Tushar Pandurang Khaladkar

Ashok Tukaram Chaudhari

Sanjay Shankar Pawar

Vijay Keshav Kalhapure

Pravin Prabhakar Ahirrao

Prasad Pandurang Panchabhai

Prabhakaran Balasubramanian

Chinmoy Mriganka Pramanik

Satyajeet Binay Biswas

Vemavarapu P K V Rao

Kiran Avinash Bapat

Pradip Nana Patil

Sandeep Anilrao Kotharkar

Balaji R Mugale

Sandip B Buchude

Nandala Srinivas

Kaliaperumal Neelakandan

Balaji Ram Mugale

Sandip Bajaba Buchude

Balaji Vasant Chaugule

Ganesh Kaluram Karhade

Kaliyaperumal Neelakandan

Ajit Sahebrao Borhade

Jayendra Dattatraya Patole

The invention relates to improved method of synthesis for Treprostinil comprising condensation reaction of the carbonyl compound having allyl, alkyl, crotyl or MEM-protected phenolic hydroxyl group, compound (4) with a hydroxyl-protected alkynol (5) to give the condensation product, compound (6). Subjecting compound (6) to oxidation, reduction, hydroxyl protection and carbonylation, cyclization reactions gave the tricyclic derivative (10). Further reactions comprising reduction, hydrogenation and deprotection of the phenolic and side-chain hydroxyl groups, wherein the sequence and choice of reagents was governed by protecting groups, gave the triol intermediate, compound (14). Cyanoalkylation at phenolic hydroxyl functionality and further hydrolysis yielded the prostacyclin compound, Treprostinil (1) and its pharmaceutically acceptable salts, having desired purity.

Process for preparation of prostacyclin derivatives

A process for preparation of diethyl 2-aetamido-2-(4-octyl phenyl)ethyl malonate (III), a key intermediate of fingolimod hydrochloride comprising reaction of 2-(4-octylphenyl)ethyl iodide (IV) with diethyl acetamido malonate in presence of a base and an iodinating agent and in an organic solvent. The compound of formula (III) thus obtained provided fingolimod hydrochloride (Ia) having associated impurities below the regulatory limits.

Fingolimod hydrochloride process

The present invention relates to the preparation of stable pyridone disulphide derivatives having general formula (I) and its stereoisomers, which are useful in the treatment of gastrointestinal disorders. Pyridone disulphide derivatives (I) wherein, R, Rand Rare independently alkyl, alkoxy, halogen, halogenated alkoxy, halogenated alkyl, hydrogen and could be the same or different and X is CH or N. Ris methyl, methoxy, fluorine, trifluoromethyl, difluoromethoxy and hydrogen, Ris methyl, methoxy and hydrogen, and Ris methyl and hydrogen.

Pyridone derivatives as acid secretion inhibitors and process for preparation thereof

The present invention provides a simple and efficient method for synthesis of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine hydrochloride. The process involves the treatment of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine free base with hydrochloric acid in water followed by isolation of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine hydrochloride of desired purity.

Process for the preparation of melphalan hydrochloride

The present invention provides a simple method for preparation of benzphetamine and its acid addition salt comprising reaction of methamphetamine hydrochloride of formula (III) with benzyl chloride and treating the isolated benzphetamine of formula (II) with an acid dissolved in an organic solvent to provide benzphetamine acid addition salt, more specifically, benzphetamine hydrochloride of formula (I).

Process for preparation of benzphetamine and its pharmaceutically acceptable salts

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Pune, India

Narendra Kumar Tripathy