Merck Sharp + Dohme Corp.

Nardos H Teumelsan

Alexander Pasternak

Haifeng Tang

Lihu Yang

Shawn P Walsh

Aurash Shahripour

Barbara A Pio

Yuping Zhu

Reynalda DeJesus

Reynalda Dejesus

This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.

Inhibitors of the renal outer medullary potassium channel

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.

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Rahway, NJ, United States of America

Nardos H Teumelsan