Postech Foundation

Postech Academy-industry Foundation

Japan Science and Technology Agency

University System of Maryland

Pohang University of Science and Technology Foundation

Narayanan Selvapalam

Kimoon Kim

Erumaipatty Rajagounder Nagarajan

Young Ho Ko

Kyeng Min Park

Yoshihisa Inoue

Dong Hyun Oh

Kangkyun Baek

Sang Yong Jon

Jeeyeon Kim

Ki-Moon Kim

Yong Ho Ko

Mikhail Rekharsky

Sung Ho Ryu

Lyle David Isaacs

Dongwoo Kim

Woo Sung Jeon

Young Jin Jeon

Ilha Hwang

Iiha Hwang

Hyunuk Kim

Don Wook Lee

Hyun Tae Jung

Youngkook Kim

Ki Moon Kim

Sang Hoon Ha

Hee Joon Kim

Ii Ha Hwang

Banerjee Mainak

Sang-Kyu Park

Young-Ho Ko

Kyeng-Min Park

Dong-Hyun Oh

Sang-Yong Jon

Simin Liu

Jeeyoun Kim

Provided is a method of separating cellular components, the method including: a) contacting a guest compound-bound reactive compound with cells; b) lysing the cells; c) adding a host compound-bound solid phase to a solution including the lysates of the cells to prepare a mixture; d) separating binding pairs of the guest compound bound to cellular components and the host compound bound to the solid phase from the mixture, and purifying the binding pairs; and e) separating the cellular components from the binding pairs, wherein the guest compound-bound reactive compound is obtained through a covalent bond between a reactive compound and a guest compound represented by Formula 2 below guest, the host compound-bound solid phase is obtained through a covalent bond between a solid phase and a host compound represented by Formula 1 below, and the reactive compound includes at least one selected from the group consisting of a biomolecule, N-hydroxysuccimide, an antigen, an antibody, an aptamer, folic acid, transferrin, and any mixtures thereof.

Method of separating and purifying cellular components using non-covalent bond between cucurbituril derivative and guest compound and apparatus using the same

Inverted cucurbituril compounds having at least one pair of hydrogen atoms protruding into an internal molecular cavity thereof.

Introverted CB[n] compounds

The present invention provides a method for quantifying a peptide compound having a phenylalanine residue at the N-terminal, comprising measuring the content of heat generated by mixing 1) a peptide compound having a phenylalanine residue at the N-terminal, 2) cucurbit[7]uril, and 3) a metal ion in a solution.

Method for determining quantity of peptide compound having phenylalanine residue at N-terminus

Provided are hydroxycucurbituril derivatives, their preparation methods and uses. The hydroxycucurbituril derivative is easy to further functionalize with enhanced solubility in common solvents, thereby providing wider applications.

Hydroxycucurbituril derivatives, their preparation methods and uses

Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.

Stationary phase and column using cucurbituril bonded silica gel, and separation method of taxol using the column

The present invention provides a method for determining in a pharmaceutical test formulation the presence or absence of a peptide compound PYYrepresented by the following amino acid sequence: H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-X (SEQ ID NO: 1), wherein X is OH or a carboxy acid-protecting group, the method comprising (1) preparing a solution by mixing the pharmaceutical test formulation with cucurbit[7]uril in a solvent; and (2) thermally analyzing the solution prepared in Step (1).

[object Object]

Provided are a gel including a compound represented by Formula 1 below and a method of preparing the same: 

Cucurbituril-containing gel and method of preparing the same

Provided are nanoparticles prepared by the aggregation of cucurbituril derivatives and having a particle size of 1 to 1,000 nm, a pharmaceutical composition in which a pharmaceutically active substance is loaded into the nanoparticles, and preparation methods thereof.

Nano-particles comprising cucurbituril derivatives, pharmaceutical composition containing the same, and process for the preparation thereof

Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.

Application using non-covalent bond between a cucurbituril derivative and a ligand

Growing community of inventors

Pohang, South Korea

Narayanan Selvapalam