Indian Institute of Technology Bombay

Narasimham Ayyagari

Irishi N N Namboothiri

Deena Jose

A compound has Formula VIII where, X is &#x2014;C(O)R, &#x2014;C(O)OR, &#x2014;CN, &#x2014;NO, &#x2014;S(O)R', &#x2014;P(O)(OR); each R is individually H, alkyl, or alkenyl; R&#x2032; is alkyl or akenyl; Ris aryl, alkenyl, arylalkenyl, heterocyclyl, or heteroaryl; and R, R, R, R, R, R, R, R, R, and Rare individually H, alkoxy, or hydroxy. In some cases, X is NO. Pharmaceutical compositions of the compound of Formula VIII with a pharmaceutically acceptable carrier may be prepared. The compounds may be used for inhibition of cyclooxygenase-2.

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Narasimham Ayyagari