Li-cor, Inc.

Visen Medical, Inc.

Narasimhachari Narayanan

Milind Rajopadhye

Ananda G Lugade

Daniel R Draney

Jeffrey D Peterson

Lyle R Middendorf

Gabor Patonay

Kevin Groves

Lucjan Strekowski

Malgorzata Lipowska

Joy Kovar

D Michael Olive

John A Brumbaugh

Xinshe Xu

William M Volcheck

Jiyan Chen

Garrick Murray Little

Harry Leonard Osterman

Ramesh Raghavachari

The invention relates to a family of compounds that comprise fluorescent cyanine dyes. The compounds are near infrared absorbing heptamethine cyanine dyes with a 4,4-disubstituted cyclohexyl ring as part of the polymethine chromophore. The compounds are generally hydrophilic and can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications.

4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof

This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N, N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.

Biocompatible N, N-disubstituted sulfonamide-containing fluorescent dye labels

This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.

This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.

Nicotinic acid and picolinic acid derived near-infrared fluorophores

Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.

Optical fluorescent imaging

The invention relates to a family of fluorescent compounds of Formula (I). The compounds can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications, and are particularly useful for the in vivo imaging of regions of interest within a mammal. 

Polycyclo dyes and use thereof

Nicotinic and picolinic acid derived near-infrared fluorophores

A compound of the formula (I) wherein the variables are defined herein. Methods of dye-labeling biomolecules with the compound of formula (I) and dye-labeled biomolecules are also provided.

Cyanine dyes

A compound of the formula (I)wherein Z is O, S, or NRwherein Ris H or alkyl; R&#x2013;Rare each independently H, alkyl, halo, carboxyl, amino, or SOCat, wherein Catis a cation and at least one of R&#x2013;Ris SOCat; Rand Rare each H, alkyl, or optionally, together with the (a) group to which they are bonded, form a ring; m and n are each independently integers from 0 to 5; X and Y are each independently O, S, Se or CRR, wherein Rand Rare each independently alkyl, or optionally form a ring together with the carbon atom to which they are bonded; Rand Rare each independently alkyl, (CH)Ror (CH)R; wherein at least one of Rand R(CH)Rand wherein r is an integer from 1 to 50, and Ris a functional group that does not directly react with a carboxyl, hydroxyl, amino, or a thiol group, and Ris a functional group that can react with a carboxyl, hydroxyl, amino, or thiol group; and R&#x2013;Rand R&#x2013;Rare each independently H, alkyl, halo, amino, sulfonato, RCOOH, ROR, RSR, or RCOORwherein Ris a bond or alkylene and Ris alkyl, or optionally Rand Rtogether with the atoms to which they are bonded form an aromatic ring, or optionally Rand Rtogether with the atoms to which they are bonded form an aromatic ring. Methods of dye-labeling biomolecules with the compound of formula (I) and dye-labeled biomolecules are also provided.

Cyanine dye compounds and labeling methods

To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.

Growing community of inventors

Westford, MA, United States of America

Narasimhachari Narayanan