University of Manitoba

Medicure, Inc.

Naranjan S Dhalla

Rajat Sethi

Krishnamurti Dakashinamurti

Krishnamurti Dakshinamurti

Hypertension in mammalian patients, especially elderly human patients, derived from ingestion of NSAIDs or through the normal aging process is treated by administration to the patient of a vitamin B.sub.6 (or derivative) supplement. Where the patient requires the continued administration of an NSAID for pharmacological purposes, the NSAID is administered in conjunction with a vitamin B.sub.6 supplement. The invention further provides combination pharmaceutical combinations of an NSAID and a vitamin B.sub.6 supplement, e.g. orally administrable tablets or capsules, for use in treating such conditions.

Treatment of iatrogenic and age-related hypertension and pharmaceutical

Compositions and methods for treatment and prevention of hypertrophy, hypertension, congestive heart failure, ischemic heart disease, ischemia-related conditions, such as ischemia reperfusion injury and cellular dysfunction, are described. The methods are directed to administering pharmaceutical compositions containing at least one compound selected from pyridoxal-5'-phosphate, pyridoxine, pyridoxal, and pyridoxamine.

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Naranjan S Dhalla