Api Corporation

Naoyuki Watanabe

Masaki Nagahama

Hiroshi Kawabata

Tomoko Maeda

Takanobu Iura

Yasumasa Dekishima

Hideki Oomiya

Takashi Ohtani

Kosuke Ito

An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.

Rosuvastatin calcium and process for producing intermediate thereof

Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound. 

Method for producing pitavastatin calcium

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Fukuoka, Japan

Naoyuki Watanabe