Takara Shuzo Co., Inc.

Takara Bio Inc.

Naoyuki Awazu

Ikunoshin Kato

Kazutoh Takesako

Mitsuhiro Ueno

Toru Kurome

Hiroyuki Mukai

Hikaru Takakura

Kazuo Shimanaka

Masanari Kitagawa

Yoshie Yoshikawa

Yoshimi Onishi

Eiko Koyama

Toshihiro Shodai

Hideharu Saito

Yoko Uno

A polypeptide having an endonuclease activity derived from a psychrophilic microorganismsp. strain Ac10, which exhibits high activity at low temperatures, can remove any nucleic acid present in a protein solution and can reduce the viscosity of a protein extract; and a nucleic acid encoding the polypeptide.

Microorganism-derived psychrophilic endonuclease

A novel cyclic peptide having an antifungal activity, its pharmacologically acceptable salts and antifungal medicinal compositions containing the same.

Cyclic peptide

Antibiotic TKR459, production method, and microorganism

Antibiotic TKR2999, process for the preparation thereof and microbe

The present invention has for its object to provide novel biologically active substances which is of value as a therapeutic agent for fungal infections and immune disorders. This invention is related to a biologically active substance TKR2449 analog(s) which is represented by the following general formula (A);

Physiologically active substances TKR2449, process for producing the same, and microorganism

Antibitic TKR2648 having the following chemical formula (I) or its pharmacologically acceptable salt.

Antibiotic TKR2648 and process for producing the same

Sphingosine derivatives and medicinal composition

Sphingosine analogues

Physiologically active substances TKR1785's, process for the preparation

Growing community of inventors

Otsu, Japan

Naoyuki Awazu