Zeria Pharmaceutical Co., Ltd.

Zeria Pharmaceuticals Co., Ltd.

Naoyoshi Miura

Tomoji Aotsuka

Yoshiaki Tanaka

Masakazu Murata

Kuniyoshi Ogura

Katsuo Shinozaki

Motoki Torizuka

Kiyoto Maeda

Naoki Nakata

Hisayoshi Kato

Mitsuo Soeda

Tomoyuki Yoneta

Masaaki Nagasawa

Kazuyasu Asami

Hiroyasu Nishioka

Heihachiro Arai

Naomi Kobayashi

Nobuo Kawase

Akihiro Okubo

Yutaka Shinozaki

Hitoshi Morita

Hikari Morita

Noaki Nakata

Hiroaki Taguchi

Hikaru Morita

A benzimidazole derivative of formula (1):(wherein R represents a hydrogen atom or a methoxy group, and n is 0 or 1) or a salt thereof; and a medicament containing the same. The compounds of the present invention, due to minimized difference in therapeutic effect between subjects, which difference would otherwise be derived from different CYP2C19 activity from subject to subject, ensure that all patients can enjoy proper therapeutic effects at the same dose of the drug. Also, the compounds of the invention have low risk of drug interaction caused by induction of CYP1A family member enzymes, as well as low risk of development of cancer, and thus is useful as a remedy for peptic ulcer, reliably providing therapeutic effects with safety.

Benzimidazole derivatives

Calcium salts of 1,5-benzodiazepine derivatives, process for producing the salts and drugs containing the same

1,5-benzodiazepine derivatives

1,5-Benzodiazepine derivatives represented by formula (I), salts thereof, and medicines containing the same as the active ingredient:

1,5 Benzodiazepine derivatives

Phenylalkanoylamine derivatives, process for preparing the same, and

Novel condensed benzene derivatives having prolyl endopeptidase inhibitory, anti-hypoxic, and anti-amnesic activities are disclosed. The compounds are represented by the following (I), ##STR1## wherein A represents a methylene, ethylene, or propylene group, B represents a methylene or ethylene group, m denotes an integer of 0-5, X and Y, which may be same or different, individually represent a methylene group or sulfur atom, R.sup.1 represents a hydrogen atom, a carboxyl, lower alkyloxycarbonyl, hydroxymethyl, or formyl group, R.sup.2 represents a hydrogen atom, a halogen atom, a lower alkyl, lower alkoxy, nitro, or amino group, R.sup.3 represents a hydrogen atom or a lower alkyl group, and the dotted line may optionally be present. They are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.

Condensed benzene derivative

Novel N-substituted amino acid imide derivatives are disclosed. The compounds are represented by formula (I): ##STR1## wherein n represents an integer of 0 to 5, and X and Y, which may be the same or different, represent a methylene group or a sulfur atom, provided that not both X and Y are methylene groups at the same time. The compounds are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.

Amino acid imide derivatives, usage thereof, and medicinal composition

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Saitama, Japan

Naoyoshi Miura