Hokkaido University

Nof Corporation

Naoya Miura

Hideyoshi Harashima

Yuta Nakai

Hidetaka Akita

Kota Tange

Hiroki Tanaka

Ayaka Watanabe

Ryohei Togashi

Mio Maeta

The present invention provides an O/W type emulsion having a volume median diameter of not more than 100 nm and containing a compound represented by the formula (1) wherein Xand Xare each independently X, Xor a 1,4-piperazinediyl group; s is 1 or 2,Ris an alkyl group having 1-6 carbon atoms,nand nare each independently 0 or 1,R, R, Rand Rare each independently an alkylene group having 1-6 carbon atoms,Yand Yare each independently an ester bond, or the like, andRand Rare each independently a liposoluble vitamin residue or the like.

O/W type emulsion

The present invention aims to provide a cationic lipid that can be used as a nucleic acid delivery carrier, a lipid membrane structure using a cationic lipid, a nucleic acid-introducing agent using a cationic lipid, and a method of achieving nucleic acid introduction by using a nucleic acid-introducing agent containing a cationic lipid. A lipid membrane structure containing a cationic lipid represented by the formula (1) wherein each symbol is as defined in the DESCRIPTION, is superior in the stability in blood and tumor accumulation property. A nucleic acid-introducing agent using the cationic lipid can achieve high nucleic acid delivery efficiency of nucleic acid to be delivered into the cytoplasm.

Cationic lipid

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Sapporo, Japan

Naoya Miura