Hamamatsu-Photonics K.k.

Hamamatsu University School of Medicine

Naoya Matsumoto

Takashi Inoue

Norihiro Fukuchi

Yuu Takiguchi

Haruyasu Ito

Koyo Watanabe

Yoshiyuki Ohtake

Taro Ando

Hirotoshi Terada

Tsutomu Hara

Yuji Kobayashi

Naohisa Mukozaka

Tomoko Otsu

Haruyoshi Toyoda

Yasunori Igasaki

Tamiki Takemori

Munenori Takumi

Akinori Asai

Koji Takahashi

Hiroshi Tanaka

Hisanari Takahashi

Kyohei Shigematsu

Shigetoshi Okazaki

Hiroyuki Suzuki

Provided is a light shaping device including: an intensity modulation unit that modulates a spectrum intensity of an optical pulse that is input light, and outputs the optical pulse of which a temporal width is narrowed as output light. The intensity modulation unit modulates the spectrum intensity of the optical pulse with a mask expressed by a starting end wavelength from a central wavelength of the input light and a wavelength width.

Light shaping device and light shaping method

A microscope apparatus includes SLMs each having a modulation plane, an objective lens disposed on an optical path between the modulation plane and an object, and a computer for controlling the SLMs on the basis of a modulation pattern including a correction pattern for correcting aberration caused by a refractive index interface of the object. The computer determines a position of the correction pattern in the modulation pattern on the basis of inclination information of the refractive index interface with respect to a plane perpendicular to an optical axis of the objective lens.

Aberration correction method and optical device

An image acquisition apparatus includes a spatial light modulator, an optical scanner, a detection unit, a control unit. The spatial light modulator performs focused irradiation on irradiation regions on a surface or inside of an observation object with modulated excitation light. The detection unit has imaging regions in an imaging relation with the irradiation regions on a light receiving surface, each of the imaging regions corresponds to one or two or more pixels, and a pixel that corresponds to none of the imaging regions exists adjacent to each imaging region. The control unit corrects a detection signal of a pixel corresponding to each imaging region on the basis of a detection signal of the pixel that exists adjacent to the imaging region and corresponds to none of the imaging regions, and generates an image of the observation object on the basis of the corrected detection signal.

Image acquisition device and image acquisition method

An image acquisition device includes a spatial light modulator modulating irradiation light, a control unit controlling a modulating pattern so that first and second light converging points are formed in an observation object, a light converging optical system converging the irradiation light, a scanning unit scanning positions of the first and second light converging points in the observation object in a scanning direction intersecting an optical axis of the light converging optical system, and a photodetector detecting first observation light generated from the first light converging point and second observation light generated from the second light converging point. The photodetector has a first detection area for detecting the first observation light and a second detection area for detecting the second observation light. The positions of the first and second light converging points are different from each other in a direction of the optical axis.

In an apparatus for modulating light, a spatial light modulator includes a plurality of pixels and configured to modulate input light in response to a drive voltage for each of the pixels. An input value setting unit is configured to set an input value for the each of pixels. The input value is a digital value, an entire gray level of the digital value is 'N', and 'N' is a natural number. A converting unit is configured to convert the input value to a control value. A control value is a digital value, an entire gray level of the control value is &#x201c;M&#x201d;, and &#x201c;M&#x201d; is a natural number greater than &#x201c;N&#x201d;. A driving unit is configured to convert the control value to a voltage value and drive the each of the pixels in response to the drive voltage corresponding to the voltage value.

Apparatus having spatial light modulator and converting unit converting input value to control value to control spatial light modulator

A photostimulation apparatus includes an objective lens arranged to face a biological object, a light source configured to output light to be radiated toward the biological object via the objective lens, a shape acquisition unit configured to acquire information about a shape with a refractive index difference in the biological object, a hologram generation unit configured to generate aberration correction hologram data for correcting aberrations due to the shape with the refractive index difference on the basis of the information acquired by the shape acquisition unit, and a spatial light modulator on which a hologram based on the aberration correction hologram data is presented and which modulates the light output from the light source.

Photostimulation device and photostimulation method

An image acquisition device includes a spatial light modulator modulating irradiation light, a control unit controlling a modulating pattern so that a plurality of light converging points are formed in an observation object, a light converging optical system converging the modulated irradiation light, a scanning unit scanning positions of the plurality of light converging points in the observation object in a scanning direction intersecting an optical axis of the light converging optical system, and a photodetector configured to detect a plurality of observation lights generated from the plurality of light converging points. The control unit sets a center spacing between adjacent light converging points on the basis of the positions of the plurality of light converging points in a direction of the optical axis.

In an aberration-correcting method according to an embodiment of the present invention, in an aberration-correcting method for a laser irradiation devicewhich focuses a laser beam on the inside of a transparent medium, aberration of a laser beam is corrected so that a focal point of the laser beam is positioned within a range of aberration occurring inside the medium. This aberration range is not less than n&#xd7;d and not more than n&#xd7;d+&#x394;s from an incidence plane of the medium, provided that the refractive index of the mediumis defined as n, a depth from an incidence plane of the mediumto the focus of the lensis defined as d, and aberration caused by the mediumis defined as &#x394;s.

Aberration-correction method, laser processing method using said aberration-correcting method, laser irradiation method using said aberration-correcting method, aberration-correcting device and aberration-correcting program

A microscope apparatus (A) includes a biological sample table () that supports the biological sample (B), an objective lens () disposed to face the biological sample table (), a laser light source () that outputs light with which the biological sample (B) is irradiated via the objective lens (), a shape measurement unit () that acquires a surface shape of the biological sample (B), a control unit () that generates aberration correction hologram data for correcting an aberration caused by the surface shape of the biological sample (B) on the basis of information acquired in the shape measurement unit (), a first spatial light modulator () to which a hologram based on the aberration correction hologram data is presented and that modulates the light output from the laser light source (), and a photodetector () that detects an intensity of light to be detected (L) generated in the biological sample (B). Thus, a microscope apparatus and an image acquisition method capable of suppressing a decrease in condensing intensity of irradiation light inside a biological sample and spreading of a condensing shape are realized.

Microscope device and image acquisition method

In an apparatus for modulating light, an spatial light modulator includes a plurality of pixels and configured to modulate input light in response to a drive voltage for each of the pixels. An input value setting unit is configured to set an input value for the each of pixels. The input value is a digital value, an entire gray level of the digital value is 'N', and 'N' is a natural number. A converting unit is configured to convert the input value to a control value. A control value is a digital value, an entire gray level of the control value is &#x201c;M&#x201d;, and &#x201c;M&#x201d; is a natural number greater than &#x201c;N&#x201d;. A driving unit is configured to convert the control value to a voltage value and drive the each of the pixels in response to the drive voltage corresponding to the voltage value.

A beam expander includes a first lens unit including one of an SLM or a VFL, a second lens unit being optically coupled to the first lens unit and including one of an SLM or a VFL, and a control unit controlling focal lengths of the first and second lens units. A distance between the first and second lens units is invariable. The control unit controls the focal lengths of the first and second lens units such that a light diameter Dof light input to the first lens unit and a light diameter Dof light output from the second lens unit are different from each other.

Beam expander

A waveform measurement device includes an input spectrum acquisition unit for acquiring an input intensity spectrum being an intensity spectrum of pulsed light, an optical element inputting the pulsed light and outputting light having an intensity spectrum corresponding to a phase spectrum of the pulsed light, an output spectrum acquisition unit for acquiring an output intensity spectrum being an intensity spectrum of the light output from the optical element, and a phase spectrum determination unit for determining the phase spectrum of the pulsed light by comparing an output intensity spectrum calculated when the pulsed light having an input intensity spectrum and a virtual phase spectrum is assumed to be input to the optical element with the output intensity spectrum acquired in the output spectrum acquisition unit. The phase spectrum determination unit sets the virtual phase spectrum by deforming the control phase spectrum.

Waveform measurement device and pulsed-light-generating device

In a light-emitting sealed body, a metal structure (electron emission structure) containing an easily electron-emitting material is used, so that it is not necessary to perform feeding for discharge between electrodes. Therefore, a feeding member does not need to be connected to the metal structure from the outside of a bulb. In addition, in the light-emitting sealed body, the metal structure is disposed in an internal space S of the bulb and a positioning unit of the metal structure is disposed only in the bulb. Therefore, in the light-emitting sealed body, the metal structure and the positioning unit do not penetrate the bulb and are not buried in the bulb and weakened portions are not formed in the bulb made of glass. Therefore, a sealing state of the bulb can be maintained surely.

Light-emitting sealed body

A total internal reflection light illumination apparatus includes a light source providing illumination light L, a spatial light modulator inputting the illumination light Land converging and outputting the illumination light Lby presenting a lens pattern, an objective lens illuminating an object substrate with illumination light Lconverged and output by the spatial light modulator, and a calculation unit providing, to the spatial light modulator, the lens pattern corresponding to at least one of a desired polarization state, desired penetration length, desired shape, and desired light intensity of the evanescent light L. The lens pattern converges the illumination light Lon a pupil plane of the objective lens.

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Hamamatsu, Japan

Naoya Matsumoto