Toray Industries, Inc.

Naotoshi Tomita

Yoshiyuki Ueno

Hiroshi Takahashi

Kaoru Shimada

Kazuhiro Tanahashi

Shungo Kanda

Junichi Kasuya

An object of the present invention is to provide a material which can remove an activated leukocyte-activated platelet complex with high efficiency. The present invention provides a material for removing an activated leukocyte-activated platelet complex, the material being a water-insoluble carrier to the surface of which carrier a compound(s) having a charged functional group(s) is(are) bound, wherein an extending length ratio of the surface is 4 to 7.

Material for removing activated leukocyte-activated platelet complex

An object of the present invention is to provide a material for blood purification having the capability to remove cytokines and activated leukocyte-activated platelet complexes. The present invention provides a material for blood purification, the material containing a water-insoluble material in which a ligand having an amide group(s) and an amino group(s) is bound to a substrate, wherein the content of the amide group(s) is 3.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material; and wherein the content of the amino group(s) is 1.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material.

Material for blood purification

A fiber for protein adsorption has a water absorption percentage of 1 to 50%, and the fiber includes a polymer containing as repeat units an aromatic hydrocarbon or a derivative thereof, wherein part of aromatic rings contained in the repeat units are cross-linked through a structure represented by Formula (I). A column for protein adsorption uses the fibers. A in Formula (I) is selected from an alkyl aliphatic group, phenyl aromatic group and amino group. 

Fiber and column for protein adsorption

An adsorption carrier-packed column includes a central pipe, adsorption carrier, plate A, and plate B, wherein an insertion material C is inserted between the adsorption carrier and the plate A; an insertion material D is inserted between the adsorption carrier and the plate B; the ratio of the deformation rate of the insertion material C (C) to the deformation rate of the adsorption carrier (E) is 1&#x3c;C/E&#x3c;10, and the ratio of the deformation rate of the insertion material D (D) to the deformation rate of the adsorption carrier (E) is 1&#x3c;D/E&#x3c;10; and the ratio of the thickness of the insertion material C (T) to the distance of a gap between the adsorption carrier and the plate A (L) is 1.1&#x3c;T/L&#x3c;4, and the ratio of the thickness of the insertion material D (T) to the distance of a gap between the adsorption carrier and the plate B (L) is 1.1&#x3c;T/L&#x3c;4.

Adsorption carrier-packed column

A carrier for blood component adsorption enables selective and efficient adsorption removal of granulocytes and monocytes and, at the same time, enables adsorption removal of inflammatory cytokines. The carrier for blood component adsorption includes a water-insoluble carrier having a surface to which a functional group(s) containing a silyl group and an amino group is/are introduced.

Carrier for blood component adsorption and blood component adsorption column

A carrier for blood component adsorption includes a water-insoluble carrier composed of a fiber or particle, the water-insoluble carrier having a surface to which a functional group(s) is/are introduced, the functional group(s) containing an acidic functional group selected from the group consisting of the sulfate group, sulfite group and sulfonate group; and containing an amino group; the fiber having a fiber diameter of, or the particle having a particle diameter of, 0.5 to 20 &#x3bc;m.

An adsorptive carrier includes one or more high-molecular-weight compounds each of which includes two or more aromatic ring-containing repeating units, the aromatic rings being covalently bound to each other via a structure represented by Formula (I): wherein Rrepresents hydrogen or an organic group, and Rrepresents an organic group.

Growing community of inventors

Otsu, Japan

Naotoshi Tomita