Terumo Kabushiki Kaisha

Teruaki Katsube

Naoto Uchida

Takeshi Shimomura

Shuichiro Yamaguchi

Noboru Oyama

Norihiko Ushizawa

Takehisa Mori

Norio Daikuhara

Satoru Kasai

In the manufacture of a substrate with a hydrophobic film used for a reference electrode of an ion sensor or the like, a hydrophobic film is formed on a substrate by irradiating a target consisting of a hydrophobic compound with a neutral atom beam and thereby effecting sputtering. The apparatus for effecting the sputtering comprises a target base disposed in a vacuum chamber, an atom beam gun for irradiating a target on the target base with a neutral beam, a substrate base and a shutter for controlling the passage of sputtered particles. A thin film that is manufactured is suitable for an ion sensor, such as an ISFET or the like or an enzyme sensor.

Apparatus for forming thin film

A reference electrode for generating a reference potential on an ion sensor is disclosed. The reference electrode has a lamination film covering a surface of an electrically conductive substrate and formed by alternately laminating silver halide thin films and hydrophobic resin thin films.

Reference electrode, ion sensor and method of manufacturing the same

Reference electrode

Ion-sensitive film, method of producing the same and ion sensor

Film-coated sensor

A biological information measurement apparatus is adapted to measure biological information in an extracorporeal circuration or in a living body by various measurement circuits comprising circuit elements which are not affected by electrical disturbances, and to transmit the results of measurement in the form of a non-electrical signal which is not affected by electrical disturbances. Measured values from measurement sections are gathered at a central processing section separated from the measurement sections. The processing section converts the measured values into output values, compensates the values for temperature and outputs the values to a display unit and recorder.

Biological information measurement apparatus

Enzyme sensor

Disclosed is an enzyme sensor for measuring a predetermined substrate concentration by potentiometric or amperometric response on the basis of an enzyme. In one aspect, a solid-state enzyme sensor measures a predetermined substrate concentration by potentiometric response and includes a solid enzyme membrane-coated electrically conductive base, redox layer or ion-sensitive layer. In another aspect, a solid-state enzyme sensor measures a predetermined substrate concentration by amperometric response and includes a solid enzyme membrane-coated oxygen reduction catalyst layer. Also disclosed is an enzyme control layer for controlling the outflow and inflow of the enzyme layer.

Growing community of inventors

Kanagawa, Japan

Naoto Uchida