University of California

Nippon Fine Chemical Co., Ltd.

Eisai R&d Management Co., Ltd.

Nagoya Institute of Technology

Shizuoka Prefectural University Corporation

Shizuoka Prefectural Universities Corporation

Sunstar Inc.

Naoto Oku

Kenneth J Shea

Yu Hoshino

Yoshiko Miura

Tomohiro Asai

Hiroyuki Koide

Yuri Nishimura

Toshiyuki Sakakibara

Yukihiro Nanba

Noriyuki Maeda

Naofumi Fukata

Koji Tomita

Takehisa Dewa

Mamoru Nango

The present invention relates generally to compositions and methods comprising abiotic, synthetic polymers with affinity and specificity to proteins. The synthetic polymers are an improvement over biological agents by providing a simpler, less expensive, and customizable platform for binding to proteins. In one embodiment, the compositions and methods relate to synthetic polymers with affinity and specificity to vascular endothelial growth factor (VEGF). In one embodiment, the compositions are useful for treating diseases and disorders related to the overexpression of VEGF. In one embodiment, the compositions are useful for treating cancer. In one embodiment, the compositions are useful for detecting VEGF levels from biological samples. In one embodiment, the compositions are useful for detecting overexpression of VEGF from biological samples. In one embodiment, the compositions are used to diagnose cancer.

Abiotic anti-VEGF nanoparticle

An object is to provide a lipid particle that is not positively charged at a pH of the body fluid (typically in the neutral range), and that enables efficient onset of the effect of a medicinal substance encapsulated in the lipid particle; and to provide a lipid for forming the lipid particle. The object is achieved by the phospholipid represented by formula (1), and a lipid particle containing the phospholipid: wherein Rand Rare identical or different, and represent a chain hydrocarbon group, m represents 1 or 2, n represents 1 or 2, and p represents an integer of 1 to 4.

Lipid derivative for nucleic acid introduction

The present invention provides novel phospholipid derivatives. Furthermore, the present invention provides lipid membrane structures excellent in gene/nucleic acid introduction efficiency into a cell.

Polycationized phospholipid derivatives

Liposomes

Growing community of inventors

Shizuoka, Japan

Naoto Oku