Cytokinetics, Inc.

Astellas Pharma Gmbh

Naoto Katoh

Bradley Paul Morgan

Pu-Ping Lu

Scott E Collibee

Susumu Yamaki

Kazuyuki Tsuchiya

Wenyue Wang

Takuya Makino

Ikumi Kuriwaki

Toshio Kurosaki

Ryuichi Sekioka

Eriko Honjo

Yuka Koizumi

Chris Evans

Makoto Yamasaki

Hideki Kubota

Tomoyuki Saito

Takafumi Shimizu

Shunichiro Matsumoto

Takatoshi Kanayama

Shigeo Matsui

Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X, X, R, R, R, R, R, and Rare as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Bicyclic 1,4-diazepanones and therapeutic uses thereof

Provided herein are compounds of formula (1): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X, X, R, R, R, R, R, and Rare as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

The present invention relates to indole carboxamide compounds of formula (I) or a salt thereof wherein R, R, R, R, R, R, Rand Rhave the meanings as indicated herein, and are MT1 and/or MT2 receptor agonists useful for treating and/or preventing urological diseases.

Indole carboxamide derivative

Growing community of inventors

Tokyo, Japan

Naoto Katoh