Mitsubishi Tanabe Pharma Corporation

Naoto Fujie

Maiko Hamada

Hiroyuki Furukawa

Seigo Ishibuchi

Masayuki Watanabe

Hiroyuki Ushio

Tooru Takashima

Minoru Tanaka

Kunitomo Adachi

Kunio Sugahara

Kenji Morokuma

Kunio Saruta

Hidemasa Hikawa

Tetsuji Matsudaira

Akiko Tarao

Junki Ando

Jun-ichi Endoh

Maki Seki

Atsushi Numata

Takashi Honjo

Shingo Ogata

Kouichi Oshita

Atsushi Kawata

Meguru Murata

Nobuatsu Matoba

Yukio Aoyama

Jun-Ichi Endoh

Provided is a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2. The present invention relates to a compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION. The compound has a selective MMP-9 production suppressive action, and is useful as a drug for the prophylaxis and/or treatment of autoimmune diseases such as rheumatoid arthritis and the like, inflammatory bowel diseases (ulcerative colitis, Crohn's disease) or osteoarthritis.

Imide derivatives and use thereof as medicine

The present invention relates to novel amidopyridine derivatives. More specifically, the present invention provides a medicinal agent which is useful as a prophylactic or therapeutic agent for diseases based on the production of cytokines from T cells, comprising as the active ingredient an amidopyridine derivative or a pharmacologically acceptable salt thereof. Provided are an amidopyridine derivative of the following general formula (I): wherein each symbol has the same meaning as defined in the description, or a pharmacologically acceptable salt thereof.

Amidopyridine derivative and use thereof

The present invention relates to a novel amide derivative. More specifically, the present invention provides a medicinal agent useful as a prophylactic or therapeutic agent for diseases, which relies on the production of cytokines from T cells, and which comprises an amide derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or the pharmacologically acceptable salt as an active ingredient. Provided is an amide derivative represented by general formula (I) [wherein each symbol is as defined in the description] or a pharmacologically acceptable salt thereof, or a solvate of the derivative or the pharmacologically acceptable salt.

Amide derivative and use thereof

A thienotriazolodiazepine compound of the following formula (I) a pharmaceutical agent containing the compound as an active ingredient, and a production intermediate and a production method of the thienotriazolodiazepine compound. Since this compound has an inhibitory action on costimulatory signal from CD28 on T cell, it is useful for the prophylaxis or suppression of rejection reaction in transplantation of organ or bone marrow and the like, and the prophylaxis or treatment of autoimmune diseases or allergic diseases.

Thienotriazolodiazepine compound and medicinal use thereof

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Osaka, Japan

Naoto Fujie