Tokyo Medical and Dental University

Naoto Arimura

Tetsuya Nagata

Takanori Yokota

Hideki Furukawa

Shigekazu Sasaki

Tomohiro Seki

Takatoshi Yogo

Kosuke Hidaka

Yasuo Nakagawa

Kenichi Miyata

Ryosuke Tokunoh

Yusuke Adachi

The object of the present invention is to provide a nucleic acid agent that can be efficiently delivered to the nervous system, particularly the central nervous system to which the BBB mechanism prevents drug delivery, and can produce an antisense effect on a target transcriptional product at the delivered site, and a composition comprising the same. Provided is a double-stranded nucleic acid complex formed by annealing a first nucleic acid strand capable of hybridizing to part of a target transcriptional product, and has an antisense effect on the target transcriptional product, to a second nucleic acid strand comprising a base sequence complementary to the first nucleic acid strand, and is bound to tocopherol or an analog thereof, cholesterol or an analog thereof, or a substituted or unsubstituted Calkyl group, a substituted or unsubstituted Calkenyl group, or a substituted or unsubstituted Calkoxy group.

BBB-crossing lipid ligand of hetero nucleic acid

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Kanagawa, Japan

Naoto Arimura