University of Tsukuba

Nippon Chemiphar Co., Ltd.

Naoshi Yamamoto

Hiroshi Nagase

Masashi Yanagisawa

Yoko Irukayama

Tsuyoshi Saitoh

Yasuyuki Nagumo

The purpose of the present invention is to provide a compound useful as a prophylactic or therapeutic agent for various diseases and symptoms related to orexin receptors, and a medical usage of the same. The present invention provides a morphinan derivative represented by the general formula (I) below or a pharmaceutically acceptable acid addition salt thereof, the morphinan derivative having excellent selectivity for and antagonism against orexin receptors and excellent therapeutic and prophylactic effects on drug dependence, and an orexin receptor antagonist and a therapeutic or prophylactic agent for drug dependence each containing it as an active ingredient. 

Morphinan derivative and medical usage thereof

A morphinan derivative represented by the following formula (I), a tautomer or a stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a medicament, an analgesic and an antipruritic drug including the same as an active ingredient: wherein R is selected from hydrogen and Calkyl, and n represents an integer of 0 to 2.

Morphinan derivative

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Tsukuba, Japan

Naoshi Yamamoto