Kuraray Co., Ltd.

Wisconsin Alumni Research Foundation

Other

Daiichi Pharmaceutical Co., Ltd.

Daiichi Sankyo Company, Limited

Naoshi Nakagawa

Hector Floyd Deluca

Tetsuo Takigawa

Takashi Takahashi

Jiro Tsuji

Masao Tsuji

Kaoru Ikeda

Takaharu Kawahara

Takeshi Moritani

Tatsuhiko Hayashibara

Yukihiro Ohara

Toshinori Tsugaru

Manzo Shiono

Akimasa Aoyama

Katsuji Ujita

Eiji Tanaka

Takanori Kitamura

Masao Mizuno

Toshifumi Akiba

Kenichi Koyakumaru

Tatsuru Saito

Hiroaki Fujii

Masafumi Okada

Tadao Shiotani

Shinji Komori

Michiya Shimamura

Masanobu Abe

Tamio Higashi

Tadashi Hatanaka

Hector F De Luca

Akira Kageyu

Akimasa Aoyama, Deceased

Shingo Ueyama

Takeshi Matsuda

A method of industrially advantageously producing a cyclopropane monoacetal derivative represented by the formula (III) conveniently and also in a fewer steps by reacting a halogenated unsaturated carbonyl compound represented by the formula (II) with an alcoholate. wherein each symbol is as defined in the specification.

Process for producing cyclopropane monoacetal derivative and intermediate therefor

A process for producing vinyl acetate polymers comprises, after polymerization of at least one monomer comprising vinyl acetate, adding a conjugated polyene having a boiling point of at least 20&deg; C. Saponified products of the vinyl acetate polymers obtained by this process can give molded articles causing little coloring and generation of gel-like agglomerates.

Resin composition comprising a saponified product of vinyl acetate polymer

A waste water treatment apparatus which is compact, and excellent in durability, has a high treatment performance and can stably operate for a long time is provided. In a waste water treatment apparatus at least comprising a waste water treatment tank in which a carrier particle immobilizing a microbe is charged and decomposing and eliminating an organic matter and/or an inorganic matter contained in a waste water, and a membrane module for filtrating a water to be treated which flows out from said treatment tank, a non-permeating water not passing thorough the membrane module is returned and circulated to said treatment tank. In a waste water treatment apparatus at least comprising a waste water treatment tank in which a carrier particle immobilizing a microbe is charged and decomposing and eliminating an organic matter and/or an inorganic matter contained in a waste water, a carrier immobilizing a microbe is an acetalized polyvinyl alcohol hydrogel.

Waste water treatment apparatus

A process for producing vinyl acetate polymers comprises, after polymerization of at least one monomer comprising vinyl acetate, adding a conjugated polyene having a boiling point of at least 20.degree. C. Saponified products of the vinyl acetate polymers obtained by this process can give molded articles causing little coloring and generation of gel-like agglomerates.

Processes for producing vinyl acetate polymer and saponified product of

1-amino-2-cyclohexene compounds represented by the following formula (I): ##STR1## wherein the substituents are as defined in the specification, a process for preparing the compounds and their use as intermediates in the production of medicinal and agricultural agents is disclosed.

1-amino-2-cyclohexene derivative and production process therefor

Vitamin D.sub.2 analogs in which a cyclopentane ring is introduced onto the 25-carbon of the side chain of 1.alpha.,25-dihydroxyvitamin D.sub.2 and its 24-epimer. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1.alpha.,25-dihydroxyvitamin D.sub.3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desired, such as osteoporosis.

26,27-dimethylene-1.alpha.,25-dihydroxyvitamin D.sub.2 and

The invention is drawn to cholesterol derivatives in which a cyclopentane ring has been introduced onto the 25-carbon of the side chain and to 24-epimers of these compounds. The compounds are useful intermediates in the production of 26,27-dimethylene-1.alpha.,25-dihydroxyvitamin D.sub.2 and 26,27-dimethylene-24-epi-1.alpha.,25-dihydroxyvitamin D.sub.2. These vitamin D derivatives are useful for the treatment of diseases such as osteoporosis.

26,27-dimethylene-1.alpha.,25-dihydroxyvitamin D.sub.2 and 26,

Vitamin D.sub.2 analogs in which a cyclopentane ring is introduced into the side chain of 1.alpha.,25-dihydroxyvitamin D.sub.2. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1.alpha.,25-dihydroxyvitamin D.sub.3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desired, such as osteoporosis.

26,28-methylene-1.alpha.,25-dihydroxyvitamin D.sub.2 compounds

Vitamin D.sub.2 analogs in which a cyclopentane ring is introduced into the side chain of 1.alpha.,25-dihydroxyvitamin D.sub.2 The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1.alpha.,25-dihydroxyvitamin D.sub.3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desired, such as osteoporosis.

26,28-methylene-1.alpha., 25-dihydroxyvitamin D.sub.2 compounds

There are provided pregnane derivatives represented by formula ##STR1## wherein A.sup.1 represents a hydrogen atom or a hydroxyl group, A.sup.2 represents a substituent such as a hydroxyl group when A.sup.1 represents a hydrogen atom, or A.sup.2 represents a hydrogen atom when A.sup.1 represents a hydroxyl group, or A.sup.1 and A.sup.2 are combined together to form an oxo group; D.sup.1 represents a substituent such as a hydroxyl group, and D.sup.2 represents a hydrogen atom, or D.sup.1 and D.sup.2 are combined together to form an epoxy group or a single bond; D.sup.3, D.sup.5 and D.sup.7 each represents a hydrogen atom, D.sup.4 represents a hydroxyl group, and D.sup.6 represents a substituent such as a hydroxyl group, or D.sup.3 and D.sup.4 may be combined together to form an epoxy group or a single bond, or D.sup.4 and D.sup.5 may be combined together to form a single bond, or D.sup.5 and D.sup.6 may be combined together to form an epoxy group or a single bond, or D.sup.6 and D.sup.7 may be combined together to form a single bond; and X.sup.1 and X.sup.2 each represents a lower alkoxyl group or, when combined together, they represent a lower alkylenedioxy or oxo group, and a process for their preparation. The pregnane derivatives are useful as intermediates for synthesizing vitamin D.sub.3 derivatives having a hydroxyl group in the 1.alpha.-position.

Pregnane derivatives and processes for production thereof

Steroid compounds

Vitamin D.sub.2 analogs in which a cyclopropane ring is introduced onto the 24-carbon of the side chain of 1.alpha.,25-dihydroxyvitamin D.sub.2 and 1.alpha.-hydroxyvitamin D.sub.2. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1.alpha.,25-dihydroxy-vitamin D.sub.3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desirbed, such as osteoporosis.

24-cyclopropane vitamin D derivatives

A method of producing .alpha.-dihydropolyprenyl monophosphates from .alpha.-dihydropolyprenols through .alpha.-dihydropolyprenyl dichlorophosphates in good yield and with ease is provided. A method of producing .alpha.-dihydropolyprenyl dichlorophosphates which are intermediate compounds useful for the first-mentioned method is also provided.

Method of producing .alpha.-dihydropolyprenyl monophosphates

Growing community of inventors

Kurashiki, Japan

Naoshi Nakagawa