Asahi Glass Company, Limited

The Green Cross Corporation

Naomichi Ishida

Takashi Okazoe

Yoshitomi Morizawa

Yoshihisa Inoue

Norifumi Nakamura

Jun Sasaki

Arata Yasuda

Hajime Ebisu

Shuzhong Wang

Tomoko Ito

Quinolin-2-yl benzoic acid compounds which are useful as intermediates of quinoline compounds having angiotensin II antagonist activity prepared by decarboxylating 2-(carboxyphenyl)-4-quinolinecarboxylic acid compounds in which a carboxyl group bonded to a phenyl group may be esterified, while a carboxyl group bonded to a quinoline ring is not esterified, and both rings may have one or more substituents inert to the decarboxylation reaction.

Process for producing 2-(carboxyphenyl)-4-quinolinecarboxylic acid

A quinoline compound represented by the formula (1) or a salt thereof: ##STR1## wherein the definition of each substituents are described in the specification, which have angiotensin II antagonism and hypotensive action and are useful as an agent for the prevention and treatment of cardiovascular system diseases such as hypertension, heart failure and the like.

Quinoline compounds

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Osaka, Japan

Naomichi Ishida