Enterprise Therapeutics Limited

Orca Pharmaceuticals Limited

Naomi Went

Clive McCarthy

Duncan Alexander Hay

Thomas Beauregard Schofield

Jonathan David Hargrave

Roine Inge Olsson

Clive Mccarthy

Compounds of general formula (I) wherein R, R, R, R, Rand X are as defined herein are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions, skin conditions and ocular conditions.

Substituted benzodiazoliums as ENaC inhibitors

The present invention discloses bis(pentahydroxyhexyl)amino substituted 2-{[(3-amino-pyrazin-2-yl)formamido]methyl}-1H-1,3-benzodiazol-3-ium derivatives of formula (I) as inhibitors of ENaC and are of use in the treatment of respiratory diseases and conditions, skin conditions or ocular conditions, wherein the respiratory disease or condition is e.g. cystic fibrosis, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiectasis, including non-cystic fibrosis bronchiectasis, and asthma; the skin condition is e.g. psoriasis, atopic dermatitis and ichthyosis; and the ocular condition is e.g. dry eye disease. 

Bis(pentahydroxyhexyl)amino substituted 2-{[(3-amino-pyrazin-2-yl)formamido]methyl}-1H-1,3-benzodiazol-3-ium derivatives as ENaC inhibitors for treating respiratory diseases

The invention relates to compounds of general formula (I): wherein R, R, R, Rand Xare as defined herein. The compounds are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions. 

Compounds

The present invention provides compounds of formula (I), wherein A, A, Z, Z, Z, R, R, R, R, R, R, n, p and q are as defined herein. In certain embodiments, the compounds of the invention are ROR&#x3b3;t antagonists. In other embodiments, the compounds of the invention are useful in the treatment and/or prevention of inflammatory and autoimmune conditions. 

Indazole and indole derivatives as inhibitors of retinoic acid related orphan receptor gamma (ROR gamma) for the treatment of immune-related diseases

The invention relates to compounds of formula (I), wherein Rand Rare as defined herein. The compounds of the invention are inhibitors of ROR&#x3b3;t and are useful in the treatment of diseases and conditions mediated by ROR&#x3b3;t. 

Indolyl-containing ROR&#x3b3;t inhibitors

The present invention relates to compounds of formula (I): wherein Rand Rare as defined herein. In certain embodiments, the compounds of the present invention are inhibitors of ROR&#x3b3;t and are useful in the treatment of diseases and conditions mediated by ROR&#x3b3;t.

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Abingdon, United Kingdom

Naomi Went