Daiichi Sankyo Company, Limited

Naomi Tanaka

Koji Matsumoto

Tsuyoshi Soneda

Taichi Fukunaga

Yuji Nakamura

Hiroki Sakai

An object of the present invention is to find a novel pharmaceutical that has an excellent tryptophanase inhibitory effect, and suppresses worsening of renal function to preserve the kidney by reducing production of indoxyl sulfate in the blood. The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound represented by the following formula, or a pharmacologically acceptable salt thereof: 

Urea derivative

An object of the present invention is to find a novel pharmaceutical that has an excellent tryptophanase inhibitory effect, and suppresses worsening of renal function to preserve the kidney by reducing production of indoxyl sulfate in the blood. Provided is a pharmaceutical composition containing, as an active ingredient, a compound represented by formula (I) or a pharmacologically acceptable salt thereof. In the formula (I), Rand Rare the same or different, and represent a C-Calkyl group, a halogeno C-Calkyl group or a C-Ccycloalkyl group; n represents 0, 1 or 2; each X represents a C-Calkyl group, a C-Ccycloalkyl group, a halogen atom or the like; and Y represents a hydrogen atom, a C-Calkoxy group, a C-Ccycloalkoxy group or a halogeno C-Calkoxy group.

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Chuo-ku, Japan

Naomi Tanaka