Zeria Pharmaceutical Co., Ltd.

H. Lundbeck A/s

Naomi Kobayashi

Yoshiaki Tanaka

Naoki Nakata

Tomoji Aotsuka

Naoyoshi Miura

Yugo Ikeda

Motoki Torizuka

Kuniyoshi Ogura

Heihachiro Arai

Itaru Yamaguchi

Tadashi Kurimoto

Tadashi Mori

Cholinesterase activator

A method for the treatment of dementia and cerebrovascular disorders and for inhibiting platelet aggregation in patients in need thereof comprising the step of administering a therapeutically effective amount of a 1-[3-(dimethylamino)propyl]-1-phenylphthalane of the general formula ##STR1## wherein R.sup.1 and R.sup.2 each are selected from the group consisting of halogen, trifluoromethyl, cyano and R--CO--, wherein R is an alkyl radical, or a pharmaceutically-acceptable acid addition salt thereof, is described.

Treatment of cerbrovascular disorders

Novel N-substituted amino acid imide derivatives are disclosed. The compounds are represented by formula (I): ##STR1## wherein n represents an integer of 0 to 5, and X and Y, which may be the same or different, represent a methylene group or a sulfur atom, provided that not both X and Y are methylene groups at the same time. The compounds are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.

Amino acid imide derivatives, usage thereof, and medicinal composition

Growing community of inventors

Konan-machi, Japan

Naomi Kobayashi