University of California

Naomi J Walker

John H Crowe

Fern Tablin

Ann E Oliver

Nelly M Tsvetkova

Willem F Wolkers

A dehydrated composition is provided that includes freeze-dried platelets. The platelets are loaded with trehalose which preserves biological properties during freeze-drying and rehydration. The trehalose loading is conducted at a temperature of from greater than about 25&deg; C. to less than about 40&deg; C., most preferably at 37&deg; C., with the loading solution having trehalose in an amount from about 10 mM to about 50 mM. These freeze-dried platelets are substantially shelf-stable and are rehydratable so as to have a normal response to an agonist, for example, thrombin, with virtually all of the platelets participating in clot formation within about three minutes at 37&deg; C.

Growing community of inventors

Davis, CA, United States of America

Naomi J Walker