Kao Corporation

Kao Corporaion

Naoko Tsuji

Shigeru Moriwaki

Yasuto Suzuki

Atsushi Ohuchi

Genji Imokawa

Yoshinori Takema

Mikako Watanabe

Yukihiro Ohashi

Yoshinori Nishizawa

Hiroshi Kusuoku

Shinya Amano

Etsuji Wakisaka

Takashi Kitahara

Satoshi Kanazawa

Yusuke Shibuya

Provided are a water-soluble ginger root extract which is a water extract or a hydrous alcohol extract of a ginger root and is substantially free of gingerols; and a hair growth inhibitor and a preparation for external use each containing the extract. The water-soluble ginger root extract of the present invention causes less skin irritation because of being substantially free of gingerols, and has excellent body-hair growth inhibiting effects, so that it is useful as a hair grown inhibitor and a preparation for external use, each having a high degree of safety.

Water-soluble ginger root extract

The present invention relates to a hair growth inhibitor and a depilation accelerator, each comprising a crude drug selected from Bupleuri Radix, Perillae Herba, Rhei Rhizoma and Akebiae Caulis, or an extract thereof. This inhibitor or accelerator makes it possible to inhibit the growth of body hair or promote depilation, respectively, thereby reducing the frequency of hair removal treatment. Moreover, it makes the hair body finer, thereby facilitating the removal of the hair from feet or arms.

Hair growth inhibitor and depilation accelerator

The present invention relates to a hair growth inhibitor and a depilation accelerator, each comprising a crude drug selected fromand, or an extract thereof. This inhibitor or accelerator makes it possible to inhibit the growth of body hair or promote depilation, respectively, thereby reducing the frequency of hair removal treatment. Moreover, it makes the hair body finer, thereby facilitating the removal of the hair from feet or arms.

Herbal hair growth inhibitor and depilation accelerator

treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.

Treating method for suppressing hair growth

A topical skin composition containing a dipeptide compound represented by formula (1) or a salt of the dipeptide: wherein Rrepresents a hydrogen atom, an alkyl group, an alkanoyl group, or &#x2014;CH(R)COOR(wherein Rrepresents a hydrogen atom or a lower alkyl group, and Rrepresents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group);

Topical composition for skin

The present invention relates to a treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.

Disclosed herein are a method of inhibiting hair growth, which comprises administering an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor, and use of an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor for the preparation of a hair-growth inhibitor.

Method of inhibiting hair growth

The present invention provides a skin external preparation comprising a compound of the formula (1), (2), (3) or (4).

Skin external preparation

The present invention provides a skin external preparation comprising a compound of the formula (1), (2), (3) or (4). ##STR1## wherein X represents COOH, etc., Z represents CONH.sub.2, etc. and R.sup.1 and R.sup.7 individually represent a hydrogen atom, etc. The above-described compound has excellent effects, for example, for preventing or alleviating skin aging or inhibiting hair growth.

Growing community of inventors

Haga-gun, Japan

Naoko Tsuji