Eisai Company, Limited

Naoko Sakabe

Shigeru Souda

Kazutoshi Miyake

Yasuhiro Akiyama

Noriyasu Hirose

Hidetoshi Kawashima

Shizuo Kuriyama

Kazuyasu Usuki

The carboximide derivatives of the formula: ##STR1## and pharmaceutically acceptable salts thereof; wherein X represents a group of the formula: ##STR2## Z represents a hydrogen atom or a group of the formula: ##STR3## wherein R represents an alkyl group, an aralkyl group, an aryl group, a cycloalkyl group, an alkenyl group, an arylalkenyl group, a pyridyl group or a substituted amino group; Y represents an alkyl group, an aralkyl group, an aryl group, a substituted or unsubstituted pyridyl group, a substituted or unsubstituted pyrimidyl group or a benzothiazolyl group; and m represents an integer of 2 or 3 and processes for the production thereof. The derivatives and their salts possess hypoglycemic activity and are useful for treating diabetes.

Piperazine substituted carboxamide derivatives, compositions and method

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Tokyo, Japan

Naoko Sakabe