Meiji Seika Kaisha, Ltd.

Naoko Miike

Takashi Yaguchi

Yuji Tabata

Toshiaki Kudo

Kenji Asai

Masaki Tsushima

Yasushi Kurata

Masahiro Hatsu

Ayako Someya

Kaori Tadauchi

Masako Imai

A medicament useful for preventive and/or therapeutic treatment of nerve system diseases which comprises, as an active ingredient, a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof:wherein, X represents a group represented by the following general formula (II), (III), (IV), (V), or (VI),'A' represents a saturated or unsaturated 3- to 6-membered carbocyclic group and the like, 'B' represents CHand the like, &#x201c;n&#x201d; represents 0 to 2, Rrepresents a hydrogen atom, a halogen atom and the like, R, R, and Rto Rrepresent a hydrogen atom, a lower alkyl group which may be substituted and the like, Rrepresents a hydrogen atom, a lower alkyl group which may be substituted and the like, Rrepresents a hydrogen atom, a halogen atom and the like, Rrepresents a saturated or unsaturated monocyclic or bicyclic carbocyclic group and the like, and Rand R, Rand R, Rand R, or Rand Rmay bind to each other to form a cyclic structure.

Phenoxyalkylamine derivatives useful as opioid &#x3b4; receptor agonists

Diphenylalkylamine derivatives useful as opioid receptor agonists

This invention provides novel physiologically active substances PF1092A, PF1092B and PF1092C, which can inhibit binding of progesterone to progesterone receptor. These substances were obtained by culturing a fungal microorganism belonging to the genus Penicillium using a medium containing ordinary nutrients for microorganisms and isolating the physiologically active substances PF1092A, PF1092B and PF1092C from the resulting culture mixture by means of solvent extraction, silica gel column chromatography, and the like. Molecular formulae of the novel physiologically active substances PF1092A, PF1092B and PF1092C are C.sub.17 H.sub.20 O.sub.5, C.sub.17 H.sub.20 O.sub.5 and C.sub.15 H.sub.18 O.sub.4, respectively.

Physiologically active substances PF1092A, PF1092B and PF1092C, process

Physiologically active substances PF1092A, PF1092B and PF1092C, and

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Kanagawa, Japan

Naoko Miike