Japan Science and Technology Agency

Wako Pure Chemical Industries, Inc.

Local Government of Aichi Prefecture

Kuraray Co., Ltd.

Naoko Kimura

Tomoya Kuwayama

Reiji Kannagi

Mineko Izawa

Shunsuke Kurei

Kazue Watanabe

Mototsugu Ninomiya

[PROBLEMS] To provide examination methods and reagents able to detect efficiently cancer patients and patients at high risk of cancer. [MEANS FOR SOLVING PROBLEMS] Significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, between non-carcinoma tissues and carcinoma tissues or adenoma tissues were discovered. The discovery is evidently applicable to detect carcinomas and adenomas (except colorectal carcinomas and colorectal adenomas) specifically by assaying a certain range of GlcNAc-6-sulfated sugar residue groups in tissues of patients and in fecal samples. Examination of carcinomas and adenomas is possible by the use of antibodies reacting specifically with GlcNAc-6-sulfated sugar residues specifically synthesized by enzymes present in carcinoma and adenoma tissues.

Method for examining carcinoma and adenoma

Growing community of inventors

Nagoya, Japan

Naoko Kimura