Asahi Kasei Kabushiki Kaisha

Asahi Kasei Medical Co., Ltd.

Naoko Ishihara

Nobuhisa Miyake

Setsuo Yamamatsu

Tamotsu Kodama

Haruyuki Minoura

Yasuhiro Nakano

There is provided a composite porous membrane comprising a porous membrane comprised of an organic polymeric compound, and a supporting porous membrane adjacent to the porous membrane, characterized in that the organic polymeric compound constituting the porous membrane penetrates in at least part of a surface adjacent to porous membrane of the supporting porous membrane, the porous membrane having specified opening ratio, average pore diameter, standard deviation of pore diameter, ratio of through pore, average membrane thickness, standard deviation of membrane thickness and internal structure, and that the supporting porous membrane has communicating pores of 0.5 D &#x3bc;m or greater average pore diameter. Further, there are provided a blood filtration membrane comprising the composite porous membrane; a leukocyte removing filter unit comprising the composite porous membrane as a second filter; and, utilizing the composite porous membrane, a cell culturing diaphragm and method of cell culturing.

Composite porous membrane and process for producing the same

A method for acylating a hexakis (arylmethyl) hexaazaisowurtzitane (WB,) by reductively removing the arylmethyl groups in the presence of an acylating agent, characterized by contacting a WB,(a) with a heterogeneous system reduction catalyst (b) in the presence of an acylating agent (c) and a reducing agent (d) in a solvent (e) for the WB,(a) to reductively remove the arylmethyl groups from the WB,(a) and acylate the same, and by preventing the WB,(a) and the catalyst (b) from being contacted with each other when at least either of the acylating agent (c) and the reducing agent (d) is not present. In this method, the decomposition of the WB,skeleton, which readily occurs in the beginning of the acylation of the WB,as a starting material, can be highly effectively inhibited. This method can hence stably produce a tetraacylhexaazaisowurtzitane derivative in a high yield and is industrially advantageous.

Method for acylating hexakis (arylmethyl) hexaazaisowurtzitane

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Kawasaki, Japan

Naoko Ishihara