Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Naoko Hata

Yasuhiro Funahashi

Takashi Owa

Toshiaki Wakabayashi

Norihiro Ueda

Akihiko Tsuruoka

Keiko Takahashi

Yuji Yamamoto

Toru Haneda

Tadashi Okabe

Kazumasa Nara

Yoichi Ozawa

Junichi Kamata

Taro Semba

Shinichi Hamaoka

Noako Tsukahara

Takeshi Nagasu

Takayuki Hida

Nozomu Koyanagi

Hiroshi Yoshino

Kentaro Yoshimatsu

Norimasa Miyamoto

Naoko Tsukahara

Kyosuke Kito

Naoto Ono

Tatsuo Okauchi

Taro Senba

The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory diseases, an anticoagulant, or a cancer metastasis suppressor on the basis of an integrin inhibitory action. Namely, it provides an integrin expression inhibitor comprising, as an active ingredient, a sulfonamide compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate of them, wherein in the formula, B means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated; K means a single bond, &#x2014;CH&#x2550;CH&#x2014; or &#x2014;(CRR)&#x2014; (wherein Rand Rare the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group; and mmeans an integer of 1 or 2); Rmeans hydrogen atom or a C1-C6 alkyl group; Z means a single bond or &#x2014;CO&#x2014;NH&#x2014;; and R means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated, respectively.

Integrin expression inhibitor

The present invention provides a system for testing the influence of a drug on integrin expression, which comprises measuring an integrin expression level in platelets of an individual to which the drug is administered and, based on the measured expression amount, determining what effect the drug has on integrin expression in cells other than platelets.

Method for testing effect of angiogenesis inhibitor via integrin expression inhibition

An appetite-stimulating agent and a therapeutic agent for anorexia, each comprising, as an active ingredient, a sulfonamide derivative or sulfonic acid ester derivative represented by the following general formula (I):

Appetite-stimulating agents and remedies for anorexia

Sulfonamide-containing heterocyclic compounds

Sulfonamide-containing indole compounds

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Ibaraki, Japan

Naoko Hata