Ajinomoto Co., Ltd.

Takeda Chemical Industries, Inc.

Yamanouchi Pharmaceutical Company Ltd.

Fujirebio Inc.

Nippon Flour Mills Co., Ltd

Naoki Yamamoto

Hideki Nakashima

Takashi Yoshida

Fukushi Hirayama

Hirokazu Yamamoto

Ryuji M Marumoto

Toshiyuki Uryu

Yoshio Taniyama

Hiroshi Ogawara

Shigenobu Kadota

Yutaro Kaneko

Keijiro Uchino

Kei Matsuzaki

Toru Mimura

Akira Fukuchi

Takumi Hamana

Masaya Iwamoto

Masashi Hiramoto

A beta-1,3-glucan of sulfated curdlan having a sulfur content of 12.4 to 17% and an average molecular weight of 27,000 to 330,000 daltons. Sulfate curdlan exhibits strong HIV inhibitory activity with little anticoagulant activity and little toxicity.

Curdlan sulfate

Sulfated tannins or salts thereof are herein disclosed. These compounds can be prepared by a method which comprises reacting tannin with a sulfonating agent under a basic condition. These compounds show antiviral activity and reverse transcriptase inhibitor, effects and can be used to treat patients infected with a variety of virus such as AIDS virus, herpesvirus, influenza virus or rhinovirus.

Sulfated tannins and their salts

A compound of the formula: ##STR1## wherein R is a hydroxyl group which may be protected and Y is a purine base which may be protected, and the saltts thereof, which are useful as an antiviral agent.

Antiviral carbocyclic purine nucleosides

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Yamaguchi, Japan

Naoki Yamamoto