Teijin Pharma Limited

Naoki Yajima

Gen Unoki

Tsuyoshi Mizuno

Hidetoshi Miyamoto

Masato Komiyama

Yuki Miyazawa

Masayuki Kurokawa

Provided is a crystal of a novel pyrido[3, 4-d]pyrimidine derivative having excellent CDK 4/6 inhibitory activity. A crystal of a compound represented by formula (I). In the formula, Rrepresents a hydrogen atom or a Calkyl group; Rrepresents a hydrogen atom or an oxo group; L represents a single bond or a Calkylene group; and X represents CH or N. 

Crystal of pyrido[3,4-d]pyrimidine derivative or solvate thereof

A process for efficiently producing, through few steps either a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or an intermediate therefore. The process is a novel coupling process which comprises subjecting a compound represented by formula (1) to coupling reaction with a compound represented by formula (2) in the presence of a transition metal compound to thereby obtain a compound represented by formula (3).

Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst

Growing community of inventors

Tokyo, Japan

Naoki Yajima