Wisconsin Alumni Research Foundation

Nagoya City University

Naoki Umezawa

Ronald Thaddeus Raines

Samuel Helmer Gellman

Yusuke Wataya

Michael A Gelman

Hye-Sook Kim

Tsunehiko Higuchi

Hirohisa Omiya

Terra Potocky

Compounds with high antimalarial activity; and antimalarial drugs containing the same as an active ingredient. There are provided compounds with antimalarial activity represented by the chemical formula: (wherein Ris H, Cl or OCH; Ris H or CH; Ris CH, CH, C(CH), CH(CH) or C(CH); Ar is imidazole, triazole, pyridine, benzene, pyrrole, furan, thiophene or derivatives thereof; n is 1 to 5; and m is 1 to 5). Further, there are provided antimalarial drugs containing these compounds with antimalarial activity or pharmacologically acceptable salts thereof as active ingredients.

Compound with antimalarial activity and antimalarial drug containing the same as active ingredient

Disclosed are &#x3b2;-peptides and &#x3b2;-peptide conjugates that are capable of diffusing or otherwise being transported across the cell membranes of living cells. The &#x3b2;-peptides contain at least six &#x3b2;-amino acid residues, at leastsix of which are preferably &#x3b2;-homoarginine residues. It has been found that when pharmacologically-active agents are conjugated to these types of &#x3b2;-peptides, the resulting conjugates (also disclosed herein) are also capable of diffusing or otherwise being transported across the cell membranes of living cells, including mammalian cells.

Method for delivery of molecules to intracellular targets

Growing community of inventors

Nagoya, Japan

Naoki Umezawa