The University of Toyama

Fuso Pharmaceutical Industries, Ltd.

Kagoshima University

Kinki University

Showa University

Naoki Toyooka

Takashi Kurihara

Hiroyuki Nishikawa

Atsufumi Kawabata

Hisashi Mori

Fumiko Sekiguchi

Ichiro Takasaki

Takayuki Obita

Syuichi Hirono

Hiroaki Gouda

Hiroaki Goda

Atsushi Kato

Isao Adachi

Mineyuki Mizuguchi

Maho Tsubota

A new analgesic has been developed for T-type calcium channels as therapeutic targets. The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1):  The present invention also provides this T-type calcium channel inhibitor, a medicament containing the T-type calcium channel inhibitor, and a therapeutic or prophylactic agent for a disease having an effective T-type calcium channel inhibitory action.

T-type calcium channel inhibitor

This invention relates to an analgesic drug comprising a compound represented by the following formula (I) or (II), wherein Ris a C-alkoxy group or a C-haloalkoxy group; Ris a hydrogen atom; and R is an indazolyl group substituted with a halogen atom; a substituted or unsubstituted phenyl group; a pyrazolyl group; or a substituted or unsubstituted aralkyl group; or a salt thereof, or a solvate thereof.

Analgesic drug using PAC1 receptor antagonistic drug

A novel serine racemase inhibitor exhibits sufficient activity and specificity. The serine racemase inhibitor includes one or more compounds selected from compounds respectively represented by the following general formulas [MM_1], [DR_1], [DR'_1], [LW_1], and [ED_1] as an active ingredient. 

Serine racemase inhibitor

A fused tricyclic compound having aldose reductase inhibitory activity and shown by the following formula, wherein Rrepresents 1 to 3 atoms or substituents selected from a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl, cycloalkyl, alkylene, or alkoxy group, and a protected or unprotected hydroxyl or carboxyl group, Rrepresents a protected or unprotected carboxyl group, Rrepresents 1 or 2 atoms or substituents selected from a hydrogen atom, a halogen atom, an oxo group, a substituted or unsubstituted alkyl or alkoxy group, and a protected or unprotected carboxyl group, A represents an alkylene group, and B represents an oxygen atom, a sulfur atom, or a group shown by the following formula, wherein Rrepresents an alkyl or aryl group substituted by an aryl, cycloalkyl, or heterocyclic group, and X represents an oxygen atom or a sulfur atom, provided that, when B represents a group shown by the following formula: wherein Rrepresents an alkyl or aryl group substituted with an aryl, cycloalkyl, or heterocyclic group, X represents a sulfur atom.

Fused tricyclic compound having aldose reductase inhibitory activity

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Toyama, Japan

Naoki Toyooka