Shiseido Company, Limited

Sogo Pharmaceutical Co., Ltd.

Koken Company, Limited

Naoki Tominaga

Teruo Miyata

Kenzo Ito

Masayasu Furuse

Makoto Tsunenaga

Yoshimaru Kumano

Toshio Nishiyama

Toshio Yoshioka

Wataru Tokue

Toru Yamashita

Mutsumi Fukuyama

Ito Kenzo

An external preparation for skin has a pH value of 2.0-5.0 and comprises: (a) 1.0-7.0 mass % of at least one of the members selected from &#x3b1;-hydroxy acids, (b) 0.1-3.0 mass % of a crosslinked type N,N-dimethylacrylamide-2-acrylamido-2-methylpropanesulfonic acid sodium salt copolymer, and (c) 0.1-3.0 mass % of an associating thickener constituted of a compound of the formula (1): R&#x2014;{(O&#x2014;R)&#x2014;OCONH&#x2014;R[&#x2014;NHCOO&#x2014;(R&#x2014;O)&#x2014;R]}(1) wherein Rrepresents a hydrocarbon group, Rand Rrepresent alkylene groups having 2-4 carbon atoms, which may be identical or different, or a phenylethylene group, Rrepresents a hydrocarbon group, which may have a urethane bond, Rrepresents a branched chain or secondary hydrocarbon group, m is a number of at least 2, h is a number of at least 1, k is a number within the range of 1-500, and n is a number within the range of 1-200.

External preparation for the skin

An anti-aging preparation for cutaneous application which prevents cutaneous aging, a collagen cross-linking inhibitory preparation for cutaneous application which inhibits collagen cross-linking occurring predominantly in the dermis to maintain skin elasticity and to prevent wrinkles or sagging, and an anti-UV preparation for cutaneous application which protects the skin from harmful effects caused by excessive exposure to ultraviolet rays of sunlight are disclosed. The preparation contains one or two aminoethyl compounds represented by formula (I):

Cosmetic composition

An external preparation containing DL-.alpha.-tocopherol 2- L-ascorbic phosphoric diester and/or a salt thereof, and at least one ultraviolet absorbing agent. The cross-linking of collagen is suppressed and an excellent cutaneous aging resisting effect is obtained.

External preparation

An anti-aging preparation for cutaneous application which prevents cutaneous aging, a collagen cross-linking inhibitory preparation for cutaneous application which inhibits collagen cross-linking occurring predominantly in the dermis to maintain skin elasticity and to prevent wrinkles or sagging, and an anti-UV preparation for cutaneous application which protects the skin from harmful effects caused by of excessive exposure to ultraviolet rays of sunlight are disclosed. The preparation contains one or two aminoethyl compounds represented by formula (I):

An external dermatological composition comprising a salt of L-arginine-L-aspartic acid and a pharmacologically acceptable carrier therefor.

External dermatological composition

An herbal composition for the body is provided which promotes lipid metabolism by increasing the activity of a lipid metabolism enzyme in the body, and which has a weight reducing effect. The composition contains at least one component selected from fennel extract, inositol and dextrane sulfate. This composition is preferably employed in the form of an invigorating herbal gel for supple skin which is effective in increasing lipase activity and thus accelerating lipid metabolism.

Invigorating herbal gel for supple skin

A hyaluronic acid-containing aqueous solution or aqueous dispersion of collagen having a pH of from about 6.5 to about 8.0 and an osmolality of from about 230 to about 320 mOsm/kgH.sub.2 O. The aqueous solution or the aqueous dispersion of collagen is useful as an agent for correction and reparation of a depressed part of or a void in soft tissue of mammals.

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Yokohama, Japan

Naoki Tominaga