Terumo Kabushiki Kaisha

Naoki Sakaguchi

Yoichiro Iwase

Takayuki Yokota

Yoshinori Hishikawa

Kazunori Koiwai

A combination of drugs having a higher antitumor effect is provided. There is provided an adjuvant composition containing a pH sensitive carrier and a natural immunity-activating substance, the adjuvant composition being used to be administered in combination with an immune checkpoint inhibitor.

Adjuvant composition, and vaccine composition and drug kit each containing the same

An adjuvant composition includes a pH-sensitive carrier and a substance with stimulus to activate innate immune system. The adjuvant composition serves as a carrier which is highly safe and capable of efficient induction of CTL.

Adjuvant composition, vaccine composition containing the same, and method for producing both of them

A method for treating tumor or inflammation in a patient in need thereof by administering a pH sensitive drug which includes a pH sensitive carrier including at least one amphipathic substance, and a physiologically active substance supported in the pH sensitive carrier to induce the pH sensitive carrier to develop a membrane disruptive function and to deliver the physiologically active substance to the site. The pH sensitive carrier can include at least one of deoxycholic acid, cholic acid, ursodeoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, C27 bile acid, glycodeoxycholic acid, glycyrrhizic acid, glycyrrhetinic acid and salts thereof, and the amphipathic substance can include at least one of a phosphatidylcholine having 10 to 12 carbon atoms, a polyoxyethylene sorbitan monofatty acid ester having 12 to 18 carbon atoms, a sorbitan fatty acid ester having 16 to 18 carbon atoms, glycerol monooleate, glycerol dilaurate, glycerol distearate, glycerol dioleate, polyoxyethylene castor oil and &#x3b1;-tocopherol.

pH sensitive carrier and preparation method thereof, and pH sensitive drug and pH sensitive drug composition each containing the carrier, and method for treating or preventing diseases using the same

A needle does not come off even if a high back pressure occurs at the skin upper section. Thus, the drug leakage from the skin can be prevented. A drug administration deviceincludes a tubular sectionhaving a fluid chambercapable of accommodating a drug and a discharge section, a pusher membermoving within the tubular section, a grip section, and a connection section. The pusher memberincludes a rod-shape plungerand a gasket. The grip sectionis disposed along the outer periphery of the tubular sectionand kept away from the tubular section, and the connection sectionis formed between the tubular sectionand the grip section

Injection needle assembly and drug injection device

A pH sensitive carrier which includes at least one pH sensitive compound selected from the group consisting of deoxycholic acid, cholic acid, ursodeoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, C27 bile acid, glycodeoxycholic acid, glycyrrhizic acid, glycyrrhetinic acid and salts thereof, and at least one amphipathic substance selected from the group consisting of a phosphatidylcholine having 10 to 12 carbon atoms, a polyoxyethylene sorbitan monofatty acid ester having 12 to 18 carbon atoms, a sorbitan fatty acid ester having 16 to 18 carbon atoms, glycerol monooleate, glycerol dilaurate, glycerol distearate, glycerol dioleate, polyoxyethylene castor oil and &#x3b1;-tocopherol, and which is capable of developing a membrane disruptive function promoting effect.

Growing community of inventors

Kanagawa, Japan

Naoki Sakaguchi