Zeria Pharmaceutical Co., Ltd.

Naoki Nakata

Yoshiaki Tanaka

Tomoji Aotsuka

Naoyoshi Miura

Kuniyoshi Ogura

Motoki Torizuka

Heihachiro Arai

Hisayoshi Kato

Naomi Kobayashi

Hiroyasu Nishioka

Mitsuo Soeda

Akihiro Okubo

Tadashi Mori

Itaru Yamaguchi

Hikari Morita

Cholinesterase activator

Arylalkanoylamine derivative and drug containing the same

Novel condensed benzene derivatives having prolyl endopeptidase inhibitory, anti-hypoxic, and anti-amnesic activities are disclosed. The compounds are represented by the following (I), ##STR1## wherein A represents a methylene, ethylene, or propylene group, B represents a methylene or ethylene group, m denotes an integer of 0-5, X and Y, which may be same or different, individually represent a methylene group or sulfur atom, R.sup.1 represents a hydrogen atom, a carboxyl, lower alkyloxycarbonyl, hydroxymethyl, or formyl group, R.sup.2 represents a hydrogen atom, a halogen atom, a lower alkyl, lower alkoxy, nitro, or amino group, R.sup.3 represents a hydrogen atom or a lower alkyl group, and the dotted line may optionally be present. They are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.

Condensed benzene derivative

Novel N-substituted amino acid imide derivatives are disclosed. The compounds are represented by formula (I): ##STR1## wherein n represents an integer of 0 to 5, and X and Y, which may be the same or different, represent a methylene group or a sulfur atom, provided that not both X and Y are methylene groups at the same time. The compounds are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.

Amino acid imide derivatives, usage thereof, and medicinal composition

Growing community of inventors

Konan, Japan

Naoki Nakata