Toyo Jozo Kabushiki Kaisha

Toyo Jozo Company, Ltd.

Asahi Kasei Kogyo Kabushiki Kaisha

Toyo Yozo Company, Ltd.

Naoki Muto

Shigeyuki Imamura

Tadashiro Fujii

Masaru Otani

Mitsuo Hayashi

Tetsu Saito

Shuzo Satoi

Hideo Misaki

Satoshi Yaginuma

Kenya Ishizawa

Masatoshi Tsujino

Akira Kodama

Kazuo Matsuura

Hideo Sakakibara

Shigeru Ikuta

Masaki Takada

Hidehiko Ishikawa

Yoshifumi Horiuchi

Junzo Mizoguchi

Masashi Awata

Masaru Ono

Seiji Katsumata

Tohru Matsumoto

Atsuki Morishita

Hitoshi Sagai

A novel .omega.-carboxyalcohol oxidase catalyzes at least one of the following reactions:

Omega carboxyalcohol oxidase enzyme

A method for assaying aliphatic alcohol, aliphatic aldehyde or .omega.-carboxylic acid derivatives thereof, using a novel .omega.-carboxyalcohol oxidase which catalyzes at least one of the following reactions:

Method for assaying aliphatic alcohol, aliphatic aldehyde or

Omega-carboxyalcohol oxidase

A antibiotic L53-18A and a pharmaceutically acceptable salt thereof which are useful for treatment of bacterial inventions are obtained by culturing, for example, Saccharopolyspora sp. L53-18 (FERM BP 2231) in a medium and the antibiotic accumulated therein is collected.

Antibiotic L53-18A and process for preparation thereof

L-glutamic acid oxidase having the following biochemical properties:

L-glutamic acid oxidase (H.sub.2 O.sub.2 -generating), its production

The invention is to provide a method for the production of sphingomyelinase, by culturing in a medium a sphingomyelinase-producing strain belonging to genus Streptomyces and collecting the resulting sphingomyelinase from the cultured medium. The strain, Streptomyces sp. A 9107, newly separated from a soil, is found preferable for the method of the present invention, and has been deposited as NRRL 15100 and FERM-P 4978.

Method for the production of sphingomyelinase

Antibiotic saccharocins of the formula ##STR1## wherein R is hydrogen (saccharocin) or hydroxyl (3'-oxysaccharocin) are produced by culturing a microorganism belonging to the genus Saccharopolyspora, for example Saccharopolyspora sp. AC 3440 FERM-P No. 6238, in a conventional nutrient medium, and separating the thus-produced saccharocins from the cultured medium. The noval saccharocins exhibit anti-bacterial activity against Gram negative bacteria.

Aminoglycoside antibiotic saccharocins

Antibiotic neplanocin A of the formula ##STR1## is produced by culturing Ampullariella sp. A 11079 FERM-P No. 4494 in a nutrient medium and then separating the neplanocin A thus produced from the culture medium.

Antibiotic neplanocin A

Aminoglycoside antibiotic G-367-2 believed to have the formula ##STR1## is produced by culturing Dactylosporangium thailandense G-367 FERM-P No. 4840 in a nutrient medium and separating the produced antibiotic therefrom. It has strong antibacterial effect against Gram negative bacteria.

Aminoglycoside antibiotic G-367-2

A novel glycerol kinase is produced from the microorganism Streptomyces canus FERM-P No. 4977 and is useful as a diagnostic reagent for assay of triglycerides and glycerol in body fluids such as serum.

Glycerol kinase from Streptomyces canus

Neplanocin-B and -F of the formula ##STR1## in which Y is oxygen or a valence bond, are produced by culturing Ampullariella sp. A 11079 FERM-P No. 4494 in a nutrient medium and then separating the neplanocin-B and -F thus produced from the culture medium.

Neplanocin-B and -F

Aminoglycoside antibiotic G-367-1 believed to have the formulae ##STR1## is produced by culturing Dactylosporangium thailandense G-367 FERM-P No. 4840 in a nutrient medium and separating the produced antibiotic therefrom. It has strong antibacterial effect against Gram negative bacteria.

Aminoglycoside antibiotic G-367-1 and method for the production thereof

A novel microorganism species belonging to the genus Micromonospora, i.e. Micromonospora sp. A 11725 is found to be capable of producing novel macrolide antibiotics A 11725 I, A 11725 II and A 11725 III. Novel antibiotics A 11725 Ia and A 11725 IIa are also found to be derived by chemical modification of the antibiotics A 11725 I and A 11725 II, respectively. All of these antibiotics or salts thereof exhibit excellent antibacterial and anti-mycoplasmal activities against various microorganisms such as Staphylococcus or Mycoplasma, and therefore useful for various purposes including medicaments.

Novel macrolide antibiotics and preparation thereof

A group of sulfur-containing antibiotics, planothiocin-A, -B, -C, -D, -E, -F and -G, are produced by culturing Actinoplanes sp. A12526 in a nutrient medium, and separating the thus-produced planothiocins therefrom. The novel antibiotics have utility in therapeutic or prophylactic antibacterial compositions or feed additives for livestock, poultry or fish.

Antibiotic planothiocins

An amino sugar compound represented by the general formula: ##STR1## (wherein m is an integer of 0 to 8, n is an integer of 1 to 8 and m+n is an integer of 1 to 8) has strong glycosidase inhibiting action and is produced by culturing an amino sugar compound producing microorganisms belonging to Streptomyces.

Growing community of inventors

Shizuoka, Japan

Naoki Muto