Sanford Burnham Prebys Medical Discovery Institute

Sony Corporation

Naoki Miyoshi

Yoshiyuki Kobayashi

Osamu Suzuki

Takashi Tsuji

Takuya Ikeda

Anthony B Pinkerton

Layton H Smith

Takahiro Nagayama

Keisuke Koide

Hirotaka Takahashi

Masaru Kawata

The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein Xrepresents —N═ or —CH═, Xrepresents —CH═ or —N═, Rand Reach represent a Cto Calkoxy group or the like, Rrepresents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and Rrepresents a Cto Calkylthio group or a Cto Calkenyl group (the Cto Calkylthio group and the Cto Calkenyl group are each optionally substituted by one carboxy group or the like) or the like.

Azole derivatives as apelin receptor agonist

The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein Xrepresents &#x2014;N&#x2550; or &#x2014;CH&#x2550;, Xrepresents &#x2014;CH&#x2550; or &#x2014;N&#x2550;, Rand Reach represent a Cto Calkoxy group or the like, Rrepresents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and Rrepresents a Cto Calkylthio group or a Cto Calkenyl group (the Cto Calkylthio group and the Cto Calkenyl group are each optionally substituted by one carboxy group or the like) or the like. 

The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein Xrepresents &#x2014;NH&#x2550; or &#x2014;CH&#x2550;, Xrepresents &#x2014;CH&#x2550; or &#x2014;N&#x2550;, Rand Reach represent a Cto Calkoxy group or the like, Rrepresents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and Rrepresents a Cto Calkylthio group or a Cto Calkenyl group (the Cto Calkylthio group and the Cto Calkenyl group are each optionally substituted by one carboxy group or the like) or the like. 

An information processing apparatus includes a hard disk drive, an acceleration sensor, and a determination section. The hard disk drive is capable of moving a head of the hard disk drive to a data-free landing zone. The acceleration sensor detects acceleration. The determination section obtains a low frequency component from the detected acceleration and determines whether it is necessary to move the head of the hard disk drive to the data-free landing zone based on the low frequency component.

Information processing apparatus having built-in hard disk drive and head retraction processing method of built-in hard disk drive

An information processing apparatus is disclosed. The information processing apparatus includes a hard disk drive, an acceleration sensor, a determination section, and a threshold value setup section. The hard disk drive is capable of retracting a head to a data-free landing zone. The acceleration sensor detects acceleration. The determination section obtains high frequency components from acceleration information detected by the acceleration sensor, obtains a vibration level corresponding to the obtained high frequency components, compares the vibration level with a threshold value which has been set up, and determines whether or not there is a necessity to retract the head of the hard disk drive to the data-free landing zone. The threshold value setup section allows a user to change the threshold value and set up the changed threshold value.

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Tokyo, Japan

Naoki Miyoshi