Eisai Company, Limited

Naoki Kobayashi

Katsuya Tagami

Shigeki Hibi

Yasushi Okamoto

Tetsuya Kawahara

Masanobu Shinoda

Hirotoshi Numata

Isao Yamatsu

Hiroyuki Yoshimura

Seiichi Kobayashi

Mitsuo Nagai

Takashi Yamanaka

Takashi Sato

Makoto Okita

Kouichi Kikuchi

Manabu Murakami

Takayuki Hida

Takashi Inoue

Kiyoshi Oketani

Naoki Tokuhara

Kenji Tai

Yumiko Nagasaka

Shinya Abe

Shigeru Souda

Hironori Ikuta

Kenji Hayashi

Yoshio Fukuda

Issei Ohtsuka

Makoto Kaino

Yoshihito Eguchi

Hironobu Hiyoshi

Ichirou Yoshida

Makoto Nakagawa

Koukichi Harada

Koichi Abe

Kaname Miyamoto

Carboxylic acid derivatives having fused rings

Fused-ring carboxylic acid derivatives

The present invention provides a medicament exhibiting excellent retinoic acid receptor agonism. A Carboxylic acid derivative having a fused ring which is represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## {wherein the symbol ##STR2## represents a single bond or a double bond; X, Y, Z, P, Q, U, V and W are each a group represented by the formula: --O-- or --S--, or a group represented by the formula: ##STR3## [wherein R.sup.k (k: 1 to 8) is hydrogen, halogeno, optionally substituted lower alkyl or the like, with either of R.sup.7 and R.sup.8 being a group represented by the formula: ##STR4## (wherein A and B are each independently an optionally substituted aromatic hydrocarbon ring or an optionally substituted unsaturated heterocycle; and D is optionally protected carboxyl)]}.

Phosphonic acid derivatives

A benzothiazole derivative or a pharmacologically acceptable salt thereof of the following formula, as defined in the claims, which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective: ##STR1##

Benzothiazole compounds which are substituted by pyridymethyl

Phosphorus-containing isoprenoid derivatives

A benzothiazole derivative or a pharmacologically acceptable salt thereof which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective. A benzothiazole derivative represented by the following general formula (I): ##STR1##

Pyridyl substituted benzothiazole compounds which have useful

The present invention is a quinone derivative which exhibits excellent therapeutic activity represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein A stands for a group represented by the formula: ##STR2## (wherein R.sup.3, R.sup.4 and R.sup.5 is the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that R.sup.3 and R.sup.4 are each a lower alkoxy group

Quinone derivatives

A benzothiazole derivative or a pharmacologically acceptable salt thereof which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective. A benzothiazole derivative represented by the following general formula (I): ##STR1## wherein R.sup.1 and R.sup.3 are either the same or different and represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; R.sup.4 represents a group represented by the formula --(CH.sub.x)--.sub.q wherein q is a integer of from 1 to 4;

Growing community of inventors

Ibaraki, Japan

Naoki Kobayashi