Shikoku Chemicals Corporation

Naoki Kano

Shozo Miura

Takayuki Murai

Natsuo Sawa

Takeshi Masuda

Kazuo Kamagata

Tadao Shimamura

Tokuichi Saeki

Masayuki Ito

Tomoko Takashige

Suzuko Satou

A process for preparing, on an industrial scale, 4-halo-5-(hydroxymethyl) imidazole compounds that are useful as intermediates for medicines. A 4-chloro-5-(hydroxymethyl) imidazole compound, a 4-bromo-5-(hydroxymethyl) imidazole compound or a like compound is synthesized by reacting a 4,5-bis(hydroxymethyl) imidazole compound with a halogenating agent such as an N-chlorosuccinimide, an N-bromosuccinimide, a chlorinated isocyanuric acid compound or the like compound.

Process for synthesizing 4-halo-5-(hydroxymethyl) imidazole compounds

Disclosed is a process for the preparation of a 1-benzylimidazole compound represented by the following general formula: ##STR1## wherein R.sub.2 represents a lower alkyl group or phenyl group, and R.sub.4 represents a hydrogen atom or a methyl group, which comprises heating and to react a 1-unsubstituted imidazole compound represented by the following general formula: ##STR2## wherein R.sub.2 and R.sub.4 are as defined above, with benzyl alcohol in the presence of a carboxylic acid, a carboxylic anhydride, a benzyl ester thereof or a lower alkyl ester thereof, and neutralizing the reaction product with an alkali.

Process for preparation of 1-benzylimidazole compound

A process for producing sodium cyanurate in the powdery form is disclosed. In this method, iso cyanuric acid is reacted with sodium carbonate or sodium hydrogencarbonate or a mixture of sodium carbonate and sodium hydrogencarbonate by mixing the raw materials in powdery form and in the presence of water in a range, in which hydrates can be formed from the raw materials at room temperature, while holding the system at a temperature at which free water can be produced.

Process of producing sodium cyanuarate

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Marugame, Japan

Naoki Kano