Fuji Yakuhin Co., Ltd

Naoki Ashizawa

Koji Matsumoto

Tsutomu Inoue

Seiichi Kobashi

Takashi Iwanaga

Hiroshi Nakamura

Takahiro Sato

Yoshinobu Aoyagi

Junichiro Uda

Osamu Nagata

Sachiho Miyata

Koichi Ishida

Hiroshige Kato

Tetsuya Taniguchi

Ryuko Tokuyama

Soichi Kaneda

It is intended to provide a novel bisphosphonic acid compound or a salt thereof which shows a remarkable inhibitory effect on ectopic calcification, and a pharmaceutical composition comprising the same. The present invention provides a bisphosphonic acid compound represented by the following formula (1) or a pharmaceutically acceptable salt thereof: whereinrepresents a single bond or a double bond; A represents a saturated cyclic hydrocarbon or a saturated heterocyclic ring comprising a sulfur atom or an oxygen atom; and Rand Reach independently represent an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an aryloxy group, a haloalkoxy group, a haloalkyl group, a halogen atom or a hydrogen atom.

Bisphosphonic acid compound

Disclosed are a novel compound and a pharmaceutical product, each having a remarkable uricosuric effect. Specifically disclosed are: a novel phenol derivative represented by general formula (1) that is shown in FIG.; a pharmaceutically acceptable salt thereof; a hydrate of the derivative or the salt; and a solvate of the derivative or the salt. (In the formula, Rand Rmay be the same or different and each represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a haloalkyl group, a haloalkoxy group, an alkylsulfanyl group, an alkylsulfinyl group, an alkylsulfonyl group, a lower alkyl-substituted carbamoyl group, a saturated nitrogen-containing heterocyclic N-carbonyl group, a halogen atom, a cyano group or a hydrogen atom; Rrepresents a lower alkyl group, a haloalkyl group, a halogen atom, a hydroxy group or a hydrogen atom; and X represents a sulfur atom, an &#x2014;S(&#x2550;O)&#x2014; group or an &#x2014;S(&#x2550;O)&#x2014; group.)

Phenol derivative

A novel 1,2,4-triazole compound which is useful as a therapeutic agent for hyperuricemia and gout due to hyperuricemia is provided. A compound is represented by the following general formula (1): wherein Rrepresents an unsubstituted or substituted pyridyl group, Rrepresents a similar pyridyl group, a pyridine-N-oxide group corresponding to these pyridyl groups, or a phenyl group, and Rrepresents hydrogen or a lower alkyl group substituted with pivaloyloxy group and Rbonds to a nitrogen atom in the ring. A process for production of a compound by reacting a nitrile and a hydrazide, and a therapeutic agent, particularly a xanthine oxidase inhibitor are also provided.

1 2 4-triazole compound

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Saitama, Japan

Naoki Ashizawa