Mercian Corporation

Other

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Naoki Agata

Takeo Yoshioka

Tomio Takeuchi

Shin-ichi Hirano

Kunio Isshiki

Hiroshi Tone

Naoki Matsumoto

Hiroyuki Kumagai

Hiroshi Iguchi

Donald W Kufe

Ralph R Weichselbaum

Masaaki Ishizuka

Masataka Shirai

Takashi Nakashima

Rokuro Okamoto

Tsutomu Sawa

Kazuo Umezawa

Norio Shibamoto

Yoshio Watanabe

Kaichiro Kominato

Masaaki Ishizuki

Toshiyuki Mase

Corinne L Reimer

Tomoyuki Kioka

Yutaka Hara

Sakino To-E

Noriaki Sakata

A method for enhancing the efficacy of chemotherapy and/or radiation in the treatment of cancer in animals, particularly humans, is provided wherein certain isocoumarin derivatives which exhibit unique radiosensitization activity and/or chemopotentiation properties are employed in a combination treatment with ionizing radiation and/or chemotherapy.

Tumor radiosensitization and/or chemopotentiation using isocoumarin derivatives

Salicylamide derivatives represented by formulae ( ) and ( ); intermediates in the production thereof; a process for producing the same; and drugs containing the same as the active ingredient. The salicylamide derivatives represented by formulae ( ) and ( ) are useful as anti-inflammatory agents and immunosuppressive agents which exert an effect of inhibiting the activation of NF-&kgr;B with little side effects.

Salicylamide derivatives

Optically active 1,4-dihydropyridine derivatives and process for the

Isocoumarin derivatives and use thereof in drugs

4-Hydroxypyridine derivative represented by the following formula ##STR1## wherein R represents a methyl group or an isopropyl group, and the method for preparing the derivative comprising the step of cultivating a strain belonging to Streptomyces karnatakensis are disclosed. Also disclosed are the pharmaceutical composition comprising the same and a method for treating circulatory diseases comprising the step of administering said compound to a patient.

4-hydroxypyridine derivatives, useful for treating circulatory diseases

Growing community of inventors

Fujisawa, Japan

Naoki Agata